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外排泵介导鲍曼不动杆菌耐药性的研究进展 被引量：6

Advances in mechanism of efflux pump from multidrug-resistant Acinetobacter baumannii
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摘要 目的鲍曼不动杆菌的多重耐药性问题日趋严重,该菌外膜上外排泵过表达是导致其耐药性的重要机制。详尽地研究多药外排泵的机制以及寻找阻断其功能的外排泵抑制剂,将为多耐药鲍曼不动杆菌的治疗开辟新的路径。本文就近年来鲍曼不动杆菌外排泵的研究现状进行综述,着重描述多药外排泵RND家族的耐药谱特征及其表达调控机制,同时,还阐述了MFS和MATE家族外排泵的研究进展。 Multidrug-resistant Acinetobacter baumannii has become an increasingly serious problem worldwide, and the main resistance mechanism is closely associated with the overexpression of the multidrug efflux transporter, which leads to expel antibiotic out of the bacterial membrane. The exact reasearch on the function and characteristic of the corresponding efflux can facilitate drug design and discovery for antibacterial therapy of multidrug-resistant A. baumannii. Therefore this review focus on research of the present efflux from A. baumarmii, especially the drugs resistant specificty and regulation of gene expression from RND family, and it evaluates progress on efflux pump from the other MFS and MATE family too.
作者 申晓冬 曾益军 何凤田
机构地区 第三军医大学基础部生物化学与分子生物学教研室
出处 《微生物学免疫学进展》 2012年第3期73-78,共6页 Progress In Microbiology and Immunology
基金 第三军医大学预研基金(2009XYY02) 重庆市自然科学基金(cstc2011jjA0560)
关键词 外排泵 鲍曼不动杆菌 多耐药性 外排泵抑制剂 Efflux Acinetobacter baumannii Multidrug-resistance Efflux pump inhibitor
分类号 R378 [医药卫生—病原生物学]
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参考文献36

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同被引文献98

  • 1Coyne S, Courvalin P, Perichon B. Efflux-mediated antibiotic resistance in Acinetobacter spp[J]. Antimicrob Agents Chemother, 2011, 55(3): 947-953.
  • 2Magnet S, Courvalin P, Lambert T. Resistance-nodulation- cell division-type efflux pump involved in aminoglycoside resistance in Aeinetobacter baumannii strain BM4454[J]. Antimicrob Agents Chemother, 2001, 45(12): 3375-3380.
  • 3Marchand I, Damier-Piolle L, Courvalin P. Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system[J]. Antimicrob Agents Chemother, 2004, 48(9): 3298-3304.
  • 4Deng M, Zhu M H, Li J J, et al. Molecular epidemiology and mechanisms of tigecycline resistance in clinical isolates of Acinetobacter baumannii from a Chinese University Hospital[J]. Antimicrob Agents Chemother, 2014, 58(1): 297-303.
  • 5Ruzin'A, Keeney D, Bradford P A. AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex[J]. J Antimicrob Chemother, 2007, 59(5): 1001-1004.
  • 6Hornsey M, Ellington M J, Doumith M, et al. AdeABC- mediated efflux and tigeeycline MICs for epidemic clones of A cinetobacter baumannii[J]. JAntimicrob Chemother, 2010, 65(8): 1589-1593.
  • 7Wong E W, Mohd Yusof M Y, Bt Mansor M, et al. Disruption ofadeB gene has a greater effect on resistance tomeropenems than adeA gene in Acinetobacter spp. isolated from University Malaya Medical Centre[J]. Singapore Med J, 2009, 50(8): 822-826.
  • 8Sun J R, Chan M C, Chang T Y, et al. Overexpression of the adeB gene in clinical isolates of tigecyeline-nonsusceptible Acinetobacter baumannii without insertion mutations in adeRS[J]. Antimierob Agents Chemother, 2010, 54(11): 4934-4938.
  • 9Sun J R, Perng C L, Chan M C, et al. A truncated AdeS kinase protein generated by ISAbal insertion correlates with tigecycline resistance in Aeinetobacter baumannii[J]. PLoS One, 2012, 7(11): e49534.
  • 10Ruzin A, ImmermAnn F W, Bradford P A. RT-PCR and statistical analyses of adeABC expression in clinical isolates of Acinetobacter caleoacetieus-Aeinetobaeter baumannii complex[J]. Microb Drug Resist, 2010, 16(2): 87-89.

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微生物学免疫学进展
2012年 第3期

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