摘要
本研究旨在探索白藜芦醇(RSV)对不同程度肥胖小鼠脂肪氧化应激状态和血脂的影响。高脂日粮(HFD)处理12周的昆明小鼠分为3类:肥胖抵抗(DIO-R)、中体重(Med)和肥胖(DIO),分别饲喂HFD、HFD+0.3 g/kg RSV和HFD+0.6 g/kg RSV日粮18周,并以正常日粮小鼠为对照。结果表明,0.6 g/kg RSV处理可显著降低DIO小鼠体重、腹脂率,显著提高脂肪组织抗氧化能力,改善血脂。0.3 g/kg RSV处理对DIO-R小鼠也有类似趋势,但0.6 g/kg RSV处理引起DIO-R小鼠脂肪组织抗氧化能力下降、血脂紊乱。总之,RSV在不同程度肥胖小鼠具有剂量特异性的氧化应激调控作用。
This study aimed to explore influence of resveratrol（RSV） on adipose tissue oxidative stress and lipid of mice with different degrees of obesity.KM mice were fed with HFD for 12 weeks.These mice belonged to three types：obesity resistant（DIO-R） mice,the medium weight（Med） and obesity（DIO） mice.Each type of mice were divided into three groups and were fed with HFD,HFD ＋0.3 g/kg RSV and HFD ＋0.6 g/kg RSV diet for 18 weeks,respectively.Mice fed with normal diet were as control.The results showed that DIO mice fed with 0.6 g/kg RSV had significantly reduced body weight,abdominal fat,blood lipid and significantly increased antioxidant capacity of adipose tissue.The phenomenon was also found in DIO-R mice which were fed with 0.3 g/kg RSV.However,0.6 g/kg RSV treatment caused significant decrease of antioxidant capacity in adipose tissue and increase of blood lipid.In summary,RSV have dose specific effect on adipose oxidative stress of mice with varying degrees of obesity.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2012年第6期832-837,共6页
Natural Product Research and Development
基金
国家自然科学基金项目(30571347)
科技部支持计划项目(2012BAD33B05)
关键词
白藜芦醇
肥胖
肥胖抵抗
氧化应激
血脂
resveratrol； obesity； obesity resistant； oxidative stress； lipids；
