摘要
目的 观察疏风解表方解热和抗炎作用。方法腹腔注射大肠杆菌内毒素（LPS）诱导大鼠发热，观察疏风解表方对发热大鼠的解热作用；腹腔注射冰醋酸诱导小鼠炎性渗出，观察疏风解表方对小鼠炎性渗出缓解作用；耳廓涂抹二甲苯诱导小鼠炎性肿胀，观察疏风解表方对小鼠炎性肿胀缓解作用。结果①模型对照组的基础体温、1h体温、2h体温、4h体温、6h体温、8h体温分别为（37．14±0．39、40．31±0．34、40．44±0．44、40．24±0．34、40．05±0．44、39．85±0．37）℃；阿司匹林组的基础体温、1h体温、2h体温、4h体温、6h体温、8h体温分别为（37．13±0．33、38．74±0．42、38．86±0．33、39．05±0．36、38．74±0．37、38．64±0．24）℃；疏风解表组的基础体温、1h体温、2h体温、4h体温、6h体温、8h体温分别为（37．03±0．46、39．02±0．49、38．82±0．49、38．63±0．46℃、38．62±0．52、38．42±0．44）℃。阿司匹林组、疏风解表组模型大鼠各时段体温均降低，与模型对照组比较差异均有统计学意义（P均〈0．01）。②各组伊文斯蓝OD值：模型对照组（0．221±0．045），阿司匹林组（0．162±0．053），疏风解表（0．176±0．049），阿司匹林、疏风解表方干预结果比较，差异无统计学意义（P〉0．05）。③耳片重量：分别为模型对照组（1．94±0．55）mg、地塞米松组（1．18±0．40）mg、疏风解表组（1．04±0．41）mg。应用地塞米松、疏风解表方干预后，耳廓肿胀程度明显降低（P均〈0．01）。结论疏风解表方具有解热抗炎作用。
Objective To observe the effect ofanti-pyretic and anti-inflammatory of Shufeng Jiebiao decoction. Methods Intraperitoneal injection of Lipopolysaccharides （LPS） was made to cause fever in rats and then to observe the anti-pyretic effect of Shufeng Jiebiao decoction. Intraperitoneal injection of glacial acetic acid was made to led inflammatory exudate in rats and then to observe the anti-inflammatory effect of Shufeng Jiebiao decoction. Smearing cylene in auricles was done to cause inflammatory swelling in rats and then to observe the effect of the alleviation of the inflammatory swelling of Shufeng Jiebiao decoction. Results The temperature of rats in the group of the aspirin and the Shufeng Jiebiao decoction were become lower at each time. The basic temperature of the model control group was （37.14±0.39） ℃, the temperature in the first hour was （40.31 ±0.34） ℃, the second hour was （40.44±0.44） ℃, the fourth hour was （40.24±0.34）℃, the sixth hour was （40.05±0.44）℃, and the eighth hour was （39.85±0.37） ℃. The basic temperature of the aspirin group was （37.13,1,0.33）℃, the temperature in the first hour was （38.74±0.42）℃, the second hour was （38.86±0.33） ℃ the fourth hour was （39.05±0.36） ℃, the sixth hour was （38.74±0.37）℃, and the eighth hour was 38.64,1,0.24） ℃. The basic temperature of the Shufeng Jiebiao decoction group was （37.03±0.46） ~C, the temperature in the first hour was （39.02±0.49）℃, the second hour was （38.82±0.49） ℃, the fourth hour was （38.63±0.46）℃, the sixth hour was （38.62±0.52） ℃, and the eighth hour was （38.42±0.44） ℃. The differences were statistical significance compared with the model control group （P〈0.01）, the onset of anti-pyretic of the Shufeng Jiebiao decoction group was slower than the aspirin group, but it had a longer lasting effect. Moreover, the rats＇ temperature decrease of the Shufeng Jiebiao decoction group in the fourth hour had a statistical significance compared with the aspirin group. （P〈0.05）.② After the intevention of aspirin and the Shufeng Jiebiao decoction, the optical density of evans blue： the model control group was （0.221±0.045）, the aspirin group was （0.162±0.053）, the Shufeng Jiebiao decoction group was （0.176±0.049）, the permeability of the abdominal capillary of the rats reduced significantly （P〈0.01）. The intervention of the aspirin and the Shufeng Jiebiao decoction had almost no difference. ③ After the intervention of the dexamethasone and the Shufeng Jiebiao decoction, the weight of the auricals： the model control group was （1.94±0.55）mg, dexamethasone group was （1.18 ±0.40） rag, Shufeng Jiebiao decoction group was （1.04 ±0.41） mg, showing the degree of the swelling of auricals decreased obviously（P〈0.01）. The intervention of the dexamethasone and the Shufeng Jiebiao decoction had almost no difference. Conclusion Shufeng Jiebiao Decoction had anti-pyretic and anti-inflammatory effects.
出处
《国际中医中药杂志》
2012年第7期613-616,共4页
International Journal of Traditional Chinese Medicine
基金
上海高校青年教师培养资助计划
关键词
疏风解表方
解热作用
抗炎作用耳片重量差
Shufeng Jiebiao decoction
Anti-pyretic effect
Anti-inflammatory effect
