摘要
目的探讨慢性丙型肝炎（chronic hepatitis C，CHC）患者发生肝脂肪变与血清瘦素水平的关系。方法将未治疗的成年CHC患者80例分为有肝脂肪变组（8例）与无肝脂肪变组（72例），以单纯非酒精性脂肪性肝病（non．alcoholic fatty liver disease，NAFLD）26例作为对照组，比较各组血清瘦素等生化指标有无差异。结果CHC有肝脂肪变组ATJT、AST水平高于NAFLD组（t=2．10，P〈0．05；f=3．56，P〈0．05），血清总胆固醇、低密度脂蛋白胆固醇、载脂蛋白A和B水平低于NAFLD组（t=-2．78，P〈0．05；f=-3．23，P〈0．05；t=-3．81，P〈0．05；t=-2．76，P〈0．05），两组瘦素水平差异无统计学意义（t=-0．30，P〉0．05）。两组CHC的ALT、AST、FPG、TG、TC、LDL-C、APO-A、APO-B、胰岛素抵抗指数、HCVRNA水平、血清瘦素水平和体质量指数差异均无统计学意义（t值分别为-1．25，0．29，0．16，43．55，0．90，1．58，1．93、0．40、0．24，43．84，旬．05、43．91，P均大于0．05）。血清瘦素水平女性显著高于男性（t=2．22，P〈0．05）。结论CHC发生肝脂肪变时炎症程度重于NAFLD，胆固醇代谢异常程度轻于NAFLD。血清瘦素水平女性高于男性。CHC发生肝脂肪变与血清瘦素水平无关。
Objective To investigate the relationship between serum leptin and hepatic steatosis in patients with chronic hepatitis C （CHC）. Methods A total of 80 adult patients with untreated CHC were divided into hepatic steatosis group （ n = 8 ） and no-steatosis group （ n = 72 ）, 26 non-alcoholic fatty liver disease（NAFLD） patients as controls. The serum leptin levels and other serum biochemical indicators were detected. Results The serum ALT and AST levels in CHC with hepatic steatosis were significantly higher than those in NAFLD （ t = 2. 10, P 〈 0.05 ; t = 3.56, P 〈 0.05 ）, while the serum total cholesterol, low density lipoprotein cholesterol, apolipoprotein - A and B were significantly lower than in NAFLD （ t = -2. 78, P 〈 0.05 ;t = -3.23 ,P 〈0.05 ;t = -3.81 ,P 〈0. 05 ;t = -2. 76 ,P 〈0.05）. But the difference of serum leptin level between CHC with hepatic steatosis and NAFLD was not significant （ t = -0. 30, P 〉 0. 05 ）. There were nosignificant difference in the serum ALT and AST levels, blood glucose levels, serum triglyceride levels, serum total cholesterol levels, serum low density lipoprotein cholesterol levels, apolipoprotein （ APO ） -A and APO-B levels ,homeostasis model assessment of insulin resistance（ HOMA-IR）, HCVRNA titer, serum leptin levels, or the BMI between two groups of CHC （t = -1.25,0. 29,0. 16,-0. 53,0. 90,1.58,1.93,0.40,0. 24,-0. 84, -0. 05 ,-0. 91, respectively, all P 〉 0. 05 ）. The serum leptin level was related to the gender, which was sig- nificantly higher in female patients than that in male patients （ t = 2. 22, P 〈 0.05 ）. Conclusion The degree of liver inflammation in CHC with hepatic steatosis is more serious than in NAFLD ,while the degree of abnor- mal cholesterol metabolism is less than in NAFLD. The level of serum leptin in female patients is significant- ly higher than that in male patients. Hepatic steatosis in CHC is not related to the levels of serum leptin.
出处
《国际病毒学杂志》
2012年第3期117-121,共5页
International Journal of Virology
基金
广东省科技计划项目专项基金（2006836005025）
关键词
肝炎
丙型
慢性
肝脂肪变
瘦素
hepatitis C, chronic
hepatic steatosis
leptin
