摘要
目的 研究 7-硝基吲唑 (7- NI)在大鼠脑缺血后的保护作用。方法 用线栓法建立大鼠大脑中动脉缺血模型。用 7- NI(选择性 n NOS抑制剂 )研究了鼠脑缺血过程中脑组织 NOS活性变化 ,脑梗死体积以及梗死外周区神经元变化。结果 7- NI明显抑制了神经元型 NOS活性 ,减少了脑梗死体积并显著减轻了神经元缺血早期变性变化。结论 7- NI对缺血急性期脑组织有明显保护作用。
Objectives To study the protective role of 7 nitroindazole(7 NI)on the focal cerebral ischemia in rats. Methods The rat model of focal cerebral ischemia were established with middle cerebral artery occlusion by the suture method 7 NI. The selective inhibitor 7 NI of neuronal nitric oxide synthase were used for investigating effects of NOS change in the focal ischemic brain tissues and changes of the cerebral infarct volume and neurons on the peripheral regions of cerebral infarct. Results 7 NI could significantly inhibit the nNOS activity,decreased infarct volume and attenuated degenerative change of neurons in early ischemic stage. Conclusions The results implied that the 7 NI had definite protective effects on the brains in ischemic acute stage.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2000年第2期69-71,共3页
Journal of Apoplexy and Nervous Diseases
基金
首都医科大学基础临床合作基金!资助课题 ( No:983 7)
