摘要
用环氧氯丙烷成功地制备出交联壳聚糖膜．用ＦＴＩＲ，ＸＲＤ和ＳＥＭ方法表征其结构，并测试了其力学性能．结果表明，壳聚糖在低温下只有氨基参与交联反应，反应温度高于４０℃时，羟基才发生反应；环氧氯丙烷的交联作用显著提高了壳聚糖膜的抗张强度，并有效地降低了溶菌酶对其降解速率；该交联膜有望用作可控降解的生物医用材料．
The crosslinked chitosan films were prepared with epichlorohydrin as a crosslinking agent, and characterized by FTIR, X-ray diffraction and SEM. Their mechanical properties were measured. The structure analysis indicated that at low temperature, the crosslinking reaction only occurred between -NH2 group of chitosan and epichlorohydrin. When the temperature was above 40 ℃, -OH group of chitosan reacted with epichlorohydrin. The results from SEM and measurement of mechanical properties showed that the tensile strength of the crosslinked films was considerably improved, and the rate of degradation of crosslinked films by lysozyme was reduced. The new crosslinked chitosan films are expected to be used as controllable degradation biomaterials.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2000年第5期809-812,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金!(批准号:29977014)
上海中金集团公司资助
关键词
壳聚糖
环氧氯丙烷
交联壳聚糖膜
生物医用材料
Chitosan
Epichlorohydrin
Crosslinked chitosan film
Mechanical properties
Lysozyme degradation
