摘要
本文叙述了分子振动光谱法 (傅立叶变换拉曼光谱技术和傅立叶变换红外光谱技术 )的最新发展与中药的无损定性鉴别、定量分析、热稳定性监控及中药优化的最新应用。报道了利用傅立叶变换拉曼光谱技术 (FT Raman)和漫反射傅立叶变换红外光谱技术 (DR FTIR)可以直接快速地鉴别生药材 ;利用漫反射傅立叶变换近红外光谱技术 (DR NIR)可以无损定量分析中药材、中成药和方剂的组分含量 ;利用FT Raman和HATR FTIR技术可望动态跟踪中药材、中成药和方剂与受体细胞、细菌的作用机制 ,以受体细胞、细菌的损伤程度来选择最佳药材或优化中药复方 ;利用FT Raman和变温FTIR可以动态跟踪药材的变质过程。这是分子振动光谱技术在中药研究应用中的新的突破。这些方法的建立对快速鉴别药材的类别、监控药材的质量、药材稳定性的预测、中药材、中成药和方剂的优化都起到较直接的指导作用。这些研究方法的特点是 :无损、快速、准确、操作简便。
The latest development of the molecular vibrational spectroscopy (Fourier Transform Raman Spectroscopy and Fourier Transform Infraed Spectroscopy) and the latest application of the non destructive identification,quantitative analysis,thermal stability monitoring and Chinese medicine optimizing were described in this paper.Some Chinese crude herbs can be directly and quickly identified by Fourier Transform Raman Spectroscopy (FT Raman) and Diffused Reflection Fourier Transform Infrared Spectroscopy (DR FTIR). The content of Chinese herbs,medicine and medicament can be quantified without destruction by Diffused Reflection Fourier Transform and Near Infrared Spectroscopy (DR NIR FTIR).The mechanism of interaction between the Chinese medicine and some cells or bacteria can be in situ monitored by FT Raman and HATR FTIR.Best medicine could be selected and medicament could be optimized according to the injury degree of the cell or bacteria.The decomposing and degenerating process of medicines can also be timely monitored by FT Raman and the temperature controlled FTIR.These are the latest use of molecular spectroscopy in Chinese medicine.The fast identification,quantitative analysis monitoring,thermal stability predicting and the optimizing of Chinese herbs,medicine and medicament can be guided by the above mentioned methods.It is proved that these methods are nondestructive to samples,fast accurate,and easy to use.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2000年第2期199-202,共4页
Spectroscopy and Spectral Analysis
关键词
光谱分析
中药
鉴别
定量分析
稳定性
NIR FT Raman, FTIR Spectroscopy, Nondestructive, Chinese medicine, Identification, Qualitative analysis, Quantitative analysis, Optimize
