摘要
目的观察风湿3号膏方治疗类风湿关节炎(RA)的临床疗效及对外周血清中IL-1和TNF-α的影响。方法 100例活动期RA患者随机分为两组,对照组(50例)常规使用甲氨蝶呤+羟氯喹+美洛昔康治疗,观察组(50例)在对照组基础上加用风湿3号膏方治疗,观察2组治疗前后各项临床和实验室指标的变化。结果观察组各项临床和实验室指标(包括关节肿胀数、关节压痛数、血沉(ESR)、C-反应蛋白(CRP)及IL-1和TNF-α)的改善程度明显优于对照组(均P<0.05)。结论在常规治疗的基础上加用风湿3号膏方治疗RA具有较好的临床疗效,对改善关节功能及降低活动期炎症指标具有较好的作用,且能明显降低外周血清中IL-1和TNF-α的表达水平。
Objective To assess the clinical efficacy of The Rheumatoid 3 Paste and its effections on the content of interleukin - 1 （ IL - 1 ） and tumor necrosis factor - α （ TNF - α） in peripheral serum in the treatment of patients with rheumatoid arthritis （RA）. Methods 100 cases of active RA patients were randomly divided into two groups,The control group（50 cases） were treated with Methotrexate （MTX） and Hydroxychloroquine and meloxicam. The Observation group（50 cases） were treated with The Rheumatoid 3 Paste on the basis of the control group, The changes of various clinical and laboratory indicators were observed before and after treatment. Results The improvements of the clinical and laboratory parameters （including the swollen joint count, tender joint count, erythrocyte sedimentation rate （ESR）, C -reactive protein（ CRP）, IL - 1 and TNF - α） of the observation group were significantly better than the control group（ P 〈 0. 05）. Conclusion Con- ventional therapy plus The Rheumatoid 3 Paste has better clinical efficacy on treatment of RA, and has a good effect to improve joint function and reduce the activity of inflammatory indicators, and could significantly reduce the expression of IL - 1 and TNF - α in peripheral serum.
出处
《湖北中医药大学学报》
2012年第3期20-22,共3页
Journal of Hubei University of Chinese Medicine
基金
十堰市科技局科学技术研究与开发指导项目(No:2010st13)
