摘要
PTEN基因是近年发现的继p53基因之后与肿瘤发生发展关系密切的抑癌基因,在血液系统肿瘤、脑胶质瘤、消化道肿瘤、妇科肿瘤、泌尿道肿瘤、肺癌、骨肉瘤等诸多肿瘤中均检测到该基因的突变或LOH,并发现其蛋白表达水平下调或缺失。
In recent years, PTEN gene is a tumor suppressor gene found following the p53 gene, correlating with the development of cancers. PTEN gene mutation or LOH, lower levels or deletion of PTEN protein expression are de- tected in many tumors such as the blood system cancer, glioma, gastrointestinal cancer, gynecological cancer, urina- ry tract cancer, lung cancer, osteosareoma.
出处
《现代肿瘤医学》
CAS
2012年第7期1507-1510,共4页
Journal of Modern Oncology
基金
国家自然科学基金资助项目(编号:30873097)
国家自然科学基金资助项目(编号:30973559)
