摘要
目的:研究PTEN基因-9C/G单核苷酸多态性与中国汉族女性人群乳腺癌之间的相关性。方法:采用基于人群的病例-对照研究,以聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法进行基因分型,检测210例中国汉族女性乳腺癌患者和210例健康女性的PTEN基因-9C/G多态性。结果:PTEN基因-9C/G位点(rs11202592)多态性基因型分布频率在两组间比较无显著性差异(P=0.862)。PTEN基因-9C/G单核甘酸多态性不同基因型间在ER、Her-2表达上无显著性差异(P>0.05)。结论:PTEN基因-9C/G位点多态性与中国汉族女性乳腺癌易感性无明显关联,ER、HER-2表达同此位点多态性也无明显关联。
Objective：To investigate the association between the PTEN -9C/G is a SNP（ single nucleotide poly- morphism ） polymorphism and breast cancer. Methods ： We conducted a population - based case - control study in 210 breast cancer patients and 210 healthy controls. The genotypes were detected by polymerase chain reaction - re- striction fragment length polymorphism （PCR - RFLP）. Results： There was no significant association between the risk of breast caner and PTEN - 9C/G polymorphisms （P = 0. 862）. There was no significant association between PTEN - 9C/G polymorphisms and ER, Her - 2 of breast cancer （ P 〉 0.05 ）. Conclusion： No significant association was oberservd between breast cancer and PTEN - 9C/G polymorphism.
出处
《现代肿瘤医学》
CAS
2012年第7期1347-1349,共3页
Journal of Modern Oncology
