摘要
用人外周血淋巴细胞和V_(79)细胞对五氧化二钒作了体外SCE 和微核试验,受试终末浓度分别为100～400μg/ml 和50～200/μg/ml。结果表明SCE 试验为阴性,而微核试验为阳性,检查了12名接触V_2O_5,粉尘的工人和12名健康者外周血淋巴细胞的SCE,结果2组间未见明显差别。根据7种短期测试系统结果预测五氧化二钒是潜在致癌物的概率为0.6615,即目前对此暂时无法下结论。
Vanadium pentoxide was tested for its cytogenetic effect.The finalconcentrations were from 100 to 400 μg/ml for lymphocytes and from50 to 200μg/ml for V_(79) cells.The results showed that SCE assay wasnegative,however micronuclcus assay was positive.A group of 12 work-ers exposed to vanadium pentoxide dust and another group of 12 noncx-posed healthy persons were examined for SCE in peripheral blood lymphocytes.No difference was found between these two groups.According tothe results of 7 short-term tests for mutagenicity,the probability of van-adium pentoxide to be potential carcinogen was calculated to have a value of 0.6615,which is premature that vanadium pentoxide is a potentialcarcinogen.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1990年第2期68-69,共2页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
五氧化二钒
细胞遗传学
致癌性
Cytogenctic sffcct
Vanadium pcntoxidc
Potcntial carcingc nicity
