摘要
目的 :评价153Sm EDTMP对多发性骨转移癌的止痛效果及消退作用。方法 :首次静脉给药剂量为 37MBq/kg。重复治疗剂量 ,结合患者病情、病灶数、血象等酌情增减。 3次为一个疗程 ,给药间隔平均 6周。结果 :15 6例骨转移患者 ,骨痛完全缓解 5 2例 (33 3% ) ,部分缓解 81例 (5 1 9% ) ,无效 2 3例 (2 1 2 % )。止痛有效率为 85 2 %(133/ 15 6 ) ,72例骨转移患者治疗后 ,病灶骨 /全身骨放射性计数率下降 5 0 %以上 14例 (19 4% )。下降 2 5 %以上 2 1例 (2 9 2 )、转移灶消退总有效率为 48 6 %。结论 :153Sm EDTMP不仅止痛效果非常显著 。
Purpose:To evaluate the value of 153 Sm EDTMP for treatment of multiple bone metastases. Methods:The intravenous injection of 37MBq/Kg of 153 Sm EDTMP was given in 156 patients with multiple bone metastases of cancer, 72 patients were followed after treatment with 99m Tc MDP bone scans.Results:The response to therapy was as follows: 33.3% (52/156) achieved complete relief of pain, 45.5% (81/156) achieved partial relief of pain and no response was found in 21.2% (23/156), the total efficiency being 85.2%. The lesion to whole bone uptake ratios decreased over 50% in 14 patients (19.4%), adecrease over 25% in 21 patients (29.2%), the total efficiency being 48.6%. Conclusions:The patients with multiple bonemetastases could be effectively treated by using 153 Sm EDTMP.
出处
《中国癌症杂志》
CAS
CSCD
2000年第2期110-111,共2页
China Oncology
