摘要
目的 :观察咪唑安定和 /或氯胺酮麻醉诱导的临床效应。方法 :全麻气管插管病人 36例 ,ASAⅠ～Ⅱ级 ,随机分为三组 ,每组 1 2例。分别静注咪唑安定 0 1mg/kg +氯胺酮 1mg/kg(Ⅰ组 )、氯胺酮 2mg/kg(Ⅱ组 )或咪唑安定0 2mg/kg(Ⅲ组 )诱导。分别记录诱导前后各组的BIS、SEF、HR及MAP等变化。结果 :①Ⅱ组诱导后BIS、SEF值低于其他组 ,而Ⅰ组诱导 2分钟后的数值≥麻醉前值 ;②Ⅰ、Ⅲ组诱导后MAP和HR值比Ⅱ组平稳 ;③Ⅱ组术后 2例出现恶梦。结论 :①咪唑安定与氯胺酮联合诱导可导致BIS、SEF值升高 ;②咪唑安定能有效预防氯胺酮引起的心血管兴奋作用及恶梦 ;③咪唑安定 0
Objective:Investigating the clinical effectiveness of co induction of midazolam and ketamine.Methods:36 patients ASA grade Ⅰ～Ⅱ,scheduled for endotracheal anesthesia were randomly allocated into 3 groups,with 12 cases each.Midazolam 0 1mg/kg together with ketamine 1mg/kg(Group Ⅰ),ketamine 2mg/kg(GroupⅡ) or midazolam 0 2mg/kg(GroupⅢ) was given intravenously.Changes in BIS,SEF,HR and MAP were recorded before and after induction.Results:①BIS and SEF value were lower in group Ⅱ than those in other groups after induction.②After induction,HR and MAP value were higher in group Ⅱ than those in the other two,nightmare was noted in 2 cases after operation in this group.Conclusion:①Co induction of midazolam and ketamine may result in the elevation of BIS and SEF value.②Midazolam can effectively prevent the cardiovascular excitability and nightmare caused by ketamine.③Midazolam 0 1mg/kg can reduce the induction dose of ketamine and shows more stable hemodynamic manifestation.
出处
《临床麻醉学杂志》
CAS
CSCD
2000年第4期180-181,共2页
Journal of Clinical Anesthesiology
