摘要
目的调查丙型肝炎病人罹患干眼的情况及相关影响因素分析。方法横断面研究。门诊病人分成病例组（丙肝患者）60人和对照组（健康人）60人，根据症状、泪膜破裂时间（BUT）、角膜荧光素染色（FL）和泪液分泌试验（SIT）来确定两组的干眼患者人数并行X。检验比较，f检验进一步比较丙肝病人组的十眼和非干眼者之间的丙肝病毒（hepatitisCvirus，HCV）感染时问、血谷丙转氨酶（AIJT）、白蛋白、HCV-RNA载量等指标，再把有意义的因素纳入二分类logistic回归分析。结果干眼患病率病例组45．0％（27／60）和对照组23．3％（14／60）之间的差异有统计学意义（X^2=6．261，P=0．012），丙肝病人中的干眼和非干眼者之间的感染时间（t=3．487，P〈0．01）和血白蛋白浓度（t-=2．450，P=0．017）差异有统计学意义，而A坍（t=0．222，P=0．852）和血HCV-RNA载量（t=1．545，P=0．128）差异无统计学意义。感染时间与血白蛋白的浓度密切相关（r=-0．912，P〈0．01）。logistic回归分析显示感染时间是丙肝病人罹患干眼的危险因素（OR〉1，P=0．007）。10％（6／60）的丙肝患者泪液中HCV-RNA的检查阳性，但与罹患干眼无关。其浓度明显低于血中病毒载量，结论丙肝患者常并发干眼，HCV感染时间越长及血白蛋白浓度越低其干眼患病风险越大，临床眼科医牛需提高认识．沣意筛杏．
Objective To investigate the influential factors on dry eye among hepatitis C pa- tients. Methods Analytical cross-sectional study： patients were divided into experimental group （60 hepatitis C patients） and contrast group （60 patients who didn＇t suffer hepatitis C）.The numbers of the two groups were decided by the symptom, BUT, FL and SIT. Z2_ Test and T-test were applied to get further comparison of the time of HCV, ALT, albumin and the HCV-RNA level between hepa- titis C patients and non- hepatitis C patients. Significant factors were analyzed by binary logistic re- gression. Results The difference of dry eye prevalence between experimental group （45.0%; 27/60） and contrast group （3.3%; 14/60） was statistically significant. Among those hepatitis C patients, the difference of the infectious time （t=3.487, P 〈0.01） and blood protein concentration （t =2.450, P = 0.017） between dry eye patients and non-dry-eye patients was statistically significant. However, the difference between ALT （t =0.222, P =0.852） and HCV-RNA levels （t =1.545, P =0.128） was not sta- tistically significant. The infectious time was relevant to blood protein concentration （r =-0.912, P 〈 0.01）. Binary logistic regression demonstrated that infectious time was the most fatal factor to develop dry eye for hepatitis C patients （OR〉l, P =0.007）. （10%; 6/60） HCV-RNA in hepatitis C patients＇tears was positive and it was not related to dry eye. The concentration of tears was obviously lower than the viral burden. Conclusions Hepatitis C patients＇ is susceptible to dry eye. The longer they suffer infection and the lower the blood protein concentration is, the risk of suffering dry eye is larg- er. Doctors are supposed to improve their awareness and be highly attentive
出处
《中国实用眼科杂志》
CSCD
北大核心
2012年第7期800-804,共5页
Chinese Journal of Practical Ophthalmology
