摘要
目的 :探讨马钱子散的药物动力学过程。方法 :以家兔肌肉诱发电位的潜伏期为指标 ,进行了马钱子散的药效动力学研究。结果 :马钱子散用药后其潜伏期明显缩短 (P <0 .0 1) ,并与给药剂量正相关 (r =0 .95 81,P <0 .0 5 )。其药效动力学过程符合血管外给药的一室开放模型。药效上升速率常数为 0 .0 790min-1;药效倍增期为 8.8min ;药效峰时间为药后 44 .1min ;药效峰强度为其潜伏期较药前缩短 4.2 3% ;药效消除速率常数为 0 .0 46 1min-1;药效半衰期为 15 .0 2min ;药效维持时间为 70 - 80min。结论 :研究结果为马钱子散的合理用药提供参考。
Objective:To study on the pharmacodynamic process of Semen Strychni Powder. Methods:The pharmacodynamics of Semen Strychni Powder was studied in the incubation period of induced myoelectric potential of rabbit as an index. Results:The incubation period obviously shortened after rabbit was given Semen Strychni Powder (P<0.01), and was positively correlated with drug dosage (r=0.9581, P<0.05). The pharmacodynamic process accorded with the one chamber open model of intravascular administration. The elevation rate constant, doubling and redoubling period of drug effect were 0.0790 min -1 and 8.8 min; the peak time of drug effect was 44.1 min after drug being given; the peak strength of drug effect was mapifested as its incubation period after drug being given was 4.23% shorter than that before drug being given; the elimination rate constant, shelf life and maintenance time of drug effect were 0.0461 min -1 , 15.02 min and 70-80 min. Conclusion:The study results will provide a reference for rational application of Semen Strychni Powder.
出处
《中成药》
CAS
CSCD
2000年第4期280-282,共3页
Chinese Traditional Patent Medicine
基金
山东省自然科学基金资助项目!No.93C1639
关键词
马钱子散
药效动力学
肌电
潜伏期
家兔
Semen Strychni
pharmacody namics
myoelectric
incubation period
