摘要
目的探讨硝普钠治疗慢性肺源性心脏病急性加重期的临床疗效。方法将我院自2008年2月~2011年2月收治的60例慢性肺源性心脏病患者随机分为对照组和观察组,每组30例。对照组采用常规治疗,观察组在对照组的基础上加用硝普钠,观察比较两组患者的临床疗效,心功能及血气改善情况。结果观察组患者中的总有效率96.67%明显高于对照组的66.67%（P〈0.01）;治疗后两组患者的心功能指标、动脉血气指标均比治疗前明显改善（P〈0.05）,且观察组的改善程度显著优于观察组（P〈0.05）;两组患者均未发生明显不良反应。结论硝普钠治疗慢性肺源性心脏病急性加重期疗效显著,可有效缓解临床症状,改善心功能,且不良反应少,值得临床推广应用。
OBJECTIVE To investigate clinical efficacy of chronic pulmonary heart disease （CPHD） treated with sodium nitroprusside. METHODS 60 patients with CPHD from February 2008 to February 2011 in our hospital were randomly divided into control group and observation group, and 30 cases of each group. The control group was given conventional treatment while the observation group was received sodium nitroprusside on the ba- sis of the control group. The clinical efficacy, cardiac function and improvement of blood gas were compared be- tween the two groups. RESULTS The total efficiency in the observation group was 96.67 % signi[icanfly higher than 66.67 % of the control group （P 〈 0. 01） ; after the treatment, the cardiac function and arterial blood gas had significantly improved than before （P 〈 0.05）, and the degree of improvement in the observation group was sig- nificantly better than the control group （P 〈 0.05）; there were no obvious adverse reactions in the two groups. CONCLUSION Sodium nitroprusside for treating with CPHD has good efficacy;it can effectively relieve symptoms and improve cardiac function, it has few adverse reactions, and it is suitable for widely used in clinical.
出处
《海峡药学》
2012年第6期66-68,共3页
Strait Pharmaceutical Journal
关键词
硝普钠
慢性肺源性心脏病
临床疗效
Sodium nitroprusside
Chronic pulmonary heart disease （CPHD）
Clinical efficacy
