摘要
目的 探讨前S1抗原及其抗体在乙型肝炎患者血清中的表达及意义。方法 用ELISA法检测 2 2例急性乙肝 ,10 0例慢性乙肝 ,16例重型乙肝和 10例肝硬化。结果 HBsAg、前S1抗原阳性率分别为 90 .9%、87.5 % ,两者无显著性差异 ;急性乙肝病程中前S1抗体阳性率逐渐降低 ;慢性乙肝中转氨酶正常组和升高组 ,前S1抗体阳性率分别为 80 .0 %、33.0 %。结论 在急、慢性乙肝病毒感染中 ,无论是前S1抗原的出现还是抗体应答 ,都将导致肝脏病变的活动。
Objective\ To study expression of the preS1 and Anti-preS1 in the serum of hepatitis B and its role.Methods\ The preS1 and Anti-preS1 was studied in 22 patients with acute hepatitis B,100 patients with postnecrotic liver cirrhosis by ELISA.Results\ There was no significantly difference between the positive rates of HBSAg,preS1.there were 90.0% and 87.5% respectively;In the acute hepatitis B,the positive rates of Anti-preS1 gradually decreased with infected time prolongatled;In the chronic hepatitis B with live function tests normal group and abnormal group.The positive rates of Anti-preS1 were 80.8% and 33.0% respectively.Conclusion\ Either preS1 appeared or the body immune responses induced by it lead to liver histopathologic activity.
出处
《江西医药》
CAS
2000年第2期70-71,共2页
Jiangxi Medical Journal
