摘要
目的:研究血管内皮生长因子C(VEGF-C)与胃癌淋巴管新生及其临床病理因素的关系。方法:收集65例胃癌患者围手术期一般临床资料和病理学资料,并进行随访。分析VEGF-C免疫组织化学表达与肿瘤组织淋巴管密度(LVD)计数的关系;对随访的54例患者作生存分析。结果:胃癌组织VEGF-C阳性表达率明显高于正常胃组织(P<0.05);胃癌组织VEGF-C阳性组、阴性组LVD计数分别为16.14±5.11、10.11±4.55,两者差异具有统计学意义(P<0.01);VEGF-C的表达及LVD计数与胃癌直径、大体类型、Lauren分型、年龄、性别、饮食、区域分布无明显相关;而与肿瘤分化程度、浸润深度、淋巴结转移、远处转移及TNM分期呈正相关(P<0.05)。胃癌组织VEGF-C阳性表达组1、2、3年复发率分别为40.1%、66.7%、79.2%,阴性表达组则分别为27.4%、31.3%、45.7%。VEGF-C阳性组1、2、3年复发率明显高于VEGF-C阴性组(P<0.01);54例随访患者,VEGF-C阳性患者总体生存率明显低于VEGF-C阴性患者(P<0.01)。结论:VEGF-C在胃癌淋巴管新生中起重要作用,其表达阳性率可作为胃癌术后一个新的预后指标。
Objective： To research on vascular endothelial growth factor-C（VEGF-C） relationship between lymphangiogenesis in gastric cancer and clinical pathological features of. Methods：Collection of 65 cases with gastric cancer during perioperative period in patients with clinical and pathological information and follow-up. Analysis of immunohistochemical expression of lymphatic vessel density and tumor VEGF-C（lymphatic vessel density, LVD） count; on a survival analysis of 54 cases in the follow-up of patients. Results： VEGF-C positive rates significantly higher than normal gastric cancer gastric tissue（P〈0.05）. Negative expression of VEGF-C-positive gastric cancer tissue expression group, group of LVD counts were 16.14 ± 5.11, 10.11 ± 4.55, difference between statistical significance（P〈0.01）. The size, type of VEGF-c expression and gastric cancer, Lauren, age, sex, diet, no clear relevance of regional distribution. Expression of VEGF-c group-positive gastric cancer recurrence rate of 1 year, 2 year, 3 year, 40.1%, 66.7%, 79.2%, respectively, Expression of VEGF-c-negative gastric cancer group, 27.4%, 31.3%, 45.7%, respectively. TP positive HCC Group 2-year, 3-year relapse rate significantly higher than the TP-negative group （P〈0.01）. In 54 cases with follow-up, VEGF-C-positive Group overall survival rates significantly lower than the negative group （P〈0.01）. Collusion： VEGF-C played an important role in the new biochemical lymphatic vessels in gastric cancer, Positive rate of expression can be used a new indicators of prognosis of gastric cancer after operation.
出处
《中国现代普通外科进展》
CAS
2012年第6期466-469,共4页
Chinese Journal of Current Advances in General Surgery
关键词
胃肿瘤
血管内皮生长因子C
淋巴管新生
临床病理因素
Stomach neoplasms
Vascular endothelial growth factor-c
Lymphangiogenesis
Clinical pathological features
