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骨髓增生异常综合征35例临床疗效分析 被引量:2

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摘要 目的探讨骨髓增生异常综合征临床诊断及治疗情况。方法对我院2009年7月至2011年9月35位骨髓增生异常综合征患者病例进行回顾性分析。结果 35例患者均根据病情予以对症支持治疗,其中8例患者口服全反式维甲酸;2例患者予以皮下注射干扰素;4例患者口服维生素D3;6例患者口服康力龙;5例患者联合应用康力龙+维生素D3;9例患者予以口服沙利度胺;1例患者予以小剂量HA方案化疗,35例患者经治疗后完全缓解12例、部分缓解14例、有效7例。结论 MDS的诊断应以细胞形态学作为基础,以细胞遗传学、分子生物学及免疫学指标为辅助,确定存在MDS异常造血克隆,明确MDS的亚型,从而进一步明确治疗方案,且在今后的临床及科研工作中继续探索更为有效的治疗MDS的方法,防止和阻断疾病的发展。
作者 付堃
出处 《中国医药指南》 2012年第16期106-107,共2页 Guide of China Medicine
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  • 1Vanlet P, Horny HP, Bennet JM, et al. Definitions and standards in the diagnosis and treatment of myelodysplatic snydromes:Consensus statements and report from a working conference [ J ]. Leuk Res,2007 ,31:727 - 736.
  • 2Komrokji RS, Bennett JM. Evolving classifications of the myelodysplastic syndromes[J]. Curr Opin,2007,14:98 - 105.
  • 3Bennett JM, Catovsky D, Daniel MT, et at. Proposals for the classification of the myelodysplastic syndromes [ J ]. Br J Haematol, 1982,51 : 189 - 199.
  • 4Germing U,Strupp C, Kuendgen A, et al. Refractory anaemia with excess of blasts ( RAEB ) : analysis of reclassification according to the WHO proposals [ J]. Br J Haematol,2006,132 : 162 - 167.
  • 5Strupp C, Gattennann N, Giagounidis A, et al. Refractory anemia with excess of blasts in transformation : analysis of reclassification according to the WHO proposals [ J ]. Leuk Res, 2003,27 : 397 - 404.
  • 6Rosati S, Mick R, Xu F, et al. Refractory cytopenia with multilineage dysplasia:further characterization of an ' unclassifiable' myelodysplastic syndrome [ J ]. Leukamia, 1996,10:20 - 26.
  • 7Cermak J, Michalova K, Brezinova J, et al. A prognostic impact of the separation of refractory cytopenia with multilineage dysplasia and 5q^- syndrome from refractory anemia in primary myelodysplastic syndrome[J]. Leu Res,2003 ,27 :221 - 229.
  • 8Brunning RD, Bennett JM, Flandrin G, et al. Myelodysplastic syndromes [ M ]//Jaffe ES, Harris NL, Stein H, et al. World Health Organization classification of tumours. Pathology & genetics. Tumours of haematopoietic and lymphoid tissues, Lyon: IARC Press,2001,62 - 73.
  • 9Vardeman JW. Herhatopathological concepts and controversies in the diagnosis and classification of myelodysplastic syndromes [ J ]. Hematology Am Soc Hematol Educ Program ,2006,199 - 204.
  • 10WLODARSKI M W, GONDEK L P, NEARMAN Z P,et al. Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aplastic anemia and myelodysplastic syndrome [J]. Blood, 2006,108:2632-2641.

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