摘要
目的 分析系统性红斑狼疮（SLE）合并正常甲状腺病态综合征（ESS）的临床特点.方法 回顾性分析比较43例合并ESS的SLE患者和50例甲状腺功能正常SLE患者的临床资料.结果 在SLE患者中,ESS的发病率随着SLE疾病活动指数（SLEDAI）评分的增加而升高;与甲功正常组比较,ESS组患者雷诺征（RP）、肺动脉高压（PAH）、浆膜腔积液发生率高（P〈0.05）,ESS组患者血沉（ESR）、24 h尿蛋白、免疫球蛋白G（IgG）、免疫球蛋白M（IgM）、抗双链DNA（ds-DNA）抗体阳性率增高（P〈0.05）,而血清白蛋白（ALB）、心脏射血分数（EF）降低（P〈0.05）.结论 SLE患者易合并ESS,当SLE患者出现RP、PAH、浆膜腔积液表现,ESR、24 h尿蛋白、IgG、IgM水平升高,ALB、心脏EF降低时,需考虑合并ESS.
Objective To investigate the clinical features and related factors of euthyroid sick syndrome （ESS） in patients with systemic lupus erythematosus （SLE）. Methods Retrospective analysis was carried out in 43 SLE with ESS and 50 SLE with normal thyroid function. Results The incidence of ESS in SLE patients was positively correlated with the level of systemic lupus erythematosus disease activity index （SLEDAI）. In 43 SLE patients with ESS, the rates of Raynaudg phenomenon（RP）, pulmonary artery hypertension（PAH） and serous cavity effusion were significantly higher than in normal thyroid function group. The levels of elythrocyte sedimentation rate（ESR） , 24 hour urine protein, immu- noglobulin A（IgA） , immunoglobulin G（IgG） , immunoglobulin M（IgM） and the rate of positive antibodies to double - stranded DNA （ds - DNA） were significantly higher, the levels of serum albumin and cardiac ejection fraction （EF）were significantly lower than in normal thyroid function group. Conclusion There is a high risk of ESS in patients with SLE. The prevalence of ESS in SLE with SLEDAI score ≥ 10, RP, PAH, serous cavity effsuion, higher levels of ESR, 24 hour urine protein, IgG, IgM, higher rates of positive antibodies to ds - DNA and lower levels of serum albumin and cardiac EF is higher than that of SLE patients without these features.
出处
《徐州医学院学报》
CAS
2012年第5期309-312,共4页
Acta Academiae Medicinae Xuzhou
