摘要
目的:研究氯霉素滴眼液的稳定性,改进其处方工艺.方法:采用加速试验,利用紫外可见光谱法测定经过加速试验以后的不同处方中的氯霉素的含量以观察其稳定性来筛选最佳处方达到临床用药的目的.空白对照用蒸馏水,检测波长在278 nm处.结果:氯霉素滴眼液的不同处方经过加速试验30 d后,四种氯霉素不同处方所含氯霉素的含量分别是87.31%、89.33%、88.21%、92.65%.结论:改进后的处方工艺可增强氯霉素滴眼液的稳定性,并提高了制剂的质量.
Objectives：To study the stability of chloramphenicol eye drops and to improve its prescription process. Methods Accelerated test, using UV - Vis spectrometry after accelerated testing of the different prescriptions after the chloramphenicol content to observe the Stability Screening the best prescription achieve the purpose of clinical drug. Distilled water control, the detection wavelength in 278nm. Results Chloram - phenicol different prescription eye drops after accelerated testing 30 days, chloramphenicol four different prescriptions contained chloramphenicol content is 87. 31%, 89. 33%, 88. 21%, 92. 65%. Conclusions Improving the prescri-ption process could significantly increase the stability of chloramphenicol eye drops, improve the quality of the preparation.
出处
《西北民族大学学报（自然科学版）》
2012年第1期64-68,共5页
Journal of Northwest Minzu University(Natural Science)
关键词
氯霉素滴眼液
处方工艺改进
含量测定
Chloramphenicol eye drops
The prescription process improvement
Determination
