摘要
人类胚胎植入过程不仅受到在进化上保守的机制调节,而且也受到人类一种独有的机制调节。有证据显示,细胞黏附分子L-选择蛋白和trophinin在人类胚胎植入过程扮演独特的角色。在本文中,我们描述了L-选择素和trophinin的黏蛋白糖配体的双重作用,也描述了trophinin相关蛋白bystin和tastin的双重作用。我们随后描述了滋养外胚层细胞和子宫内膜上皮细胞中由trophinin调节的信号转导。本综述也涵盖了钙依粘连蛋白和整合素在人类胚胎植入过程中的作用。
The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms,but also by a mechanism unique to humans.Evidence suggests that the cell adhesion molecules,L-selectin and trophinin,play a unique role in human embryo implantation.Here,we describe the dual roles of mucin carbohydrate ligand for L-selectin and trophinin protein and of the trophinin-associated proteins bystin and tastin.We then describe trophinin-mediated signal transduction in trophectoderm cells and endometrial epithelial cells.This review also covers cadherin and integrin in human embryo implantation.
出处
《生理学报》
CAS
CSCD
北大核心
2012年第3期247-258,共12页
Acta Physiologica Sinica
关键词
胚胎植入
促性腺激素
凋亡
embryonic implantation
gonadotrophin
apoptosis
