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卡托普利预处理对急性心肌损伤大鼠CT-1 mRNA和gp130 mRNA表达的影响及意义 被引量:1

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摘要 目的研究心肌营养素1(CT-1)及其受体gp130在异丙基肾上腺素(Iso)致大鼠急性心肌损伤中的保护作用。方法将Wistar雄性大白鼠随机分为3组:对照组、Iso损伤组,卡托普利(Cap)预处理组;用光镜观察心肌组织的病理变化,用生化方法检测心肌酶,用RT-PCR方法检测心肌组织CT-1 mRNA、gp130 mRNA的表达。结果 Cap预处理组与Iso损伤组比较,心肌坏死面积减小,肌酸激酶(CK)、谷氨酸氨基转移酶(GOT)、乳酸脱氢酶(LDH)降低,CT-1 mRNA和gp130 mRNA表达增高(P<0.01,P<0.05)。结论 Cap预处理可能通过促进CT-1的表达保护心肌。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第12期2554-2556,共3页 Chinese Journal of Gerontology
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共引文献7

同被引文献13

  • 1刘滨,李红莉,刘阳,周令望,于维汉.大鼠急性心肌损伤E选择素和细胞因子的变化[J].中国地方病学杂志,2005,24(2):158-160. 被引量:8
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  • 5Reiji Hattori,Nilanjana Maulik,Hajime Otani,Li Zhu,Gerald Cordis,Richard M. Engelman,M.A.Q. Siddiqui,Dipak K. Das.Role of STAT3 in Ischemic Preconditioning[J].Journal of Molecular and Cellular Cardiology.2001(11)
  • 6Masanobu Funamoto,Shigemichi Hishinuma,Yasushi Fujio,Yoichi Matsuda,Keita Kunisada,Hidemasa Oh,Shinji Negoro,Eiroh Tone,Tadamitsu Kishimoto,Keiko Yamauchi-Takihara.Isolation and Characterization of the Murine Cardiotrophin-1 Gene: Expression and Norepinephrine-Induced Transcriptional Activation[J].Journal of Molecular and Cellular Cardiology.2000(7)
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  • 8周艳,李淑波,张媛,顾明.卡托普利预处理对大鼠急性心肌损伤的保护作用及其对心肌细胞凋亡的影响[J].吉林医学,2009,30(21):2567-2569. 被引量:2
  • 9顾明,马鸿雁,李玉芹,车兆梅.卡托普利预处理对急性心肌损伤大鼠CT-1及凋亡相关基因表达的影响[J].中国地方病防治,2011,26(3):172-175. 被引量:2
  • 10余江恒,宋碧辉,李法琦.CT-1mRNA和gp130在高血压大鼠心肌中的表达变化及意义[J].基层医学论坛,2013,17(1):18-20. 被引量:2

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