摘要
目的 探讨脂质过氧化反应与老年性白内障的发病关系。方法 本文测定了 39例老年性白内障患者晶状体 MDA含量、SOD活力 ;48例血浆 MDA含量、红细胞 SOD活力 ,并以 12例正常人对照。结果 老年性白内障患者晶状体内 MDA含量高于对照组 (P<0 .0 5 ) ,SOD活力显著低于对照组 (P<0 .0 1) ,眼内脂质过氧化损伤明显增强 ;血浆 MDA含量显著高于对照组 (P<0 .0 1) ,红细胞 SOD活力低于显著对照组 (P<0 .0 1) ,机体脂质过氧化水平明显升高。结论 自由基引发的脂质过氧化损伤增强、机体抗氧化能力降低与老年性白内障的发病有密切关系 ;晶状体的过氧化损伤及眼内抗氧化能力降低与整体的抗氧化酶活力降低有关。
Objective To approach the pathogenesis relationship between lipid peroxidation and senile cataract(SC).Methods The malondialdehyde(MDA) contents and superoxide dismutase(SOD) activities of 39 SC lenses and the plasma MDA contents and erythrocyte SOD activities of 48 SC patients(SC group) were determined and compared with that of 12 healthy individuals(control group).Results The MDA contents of the lenses were increased ( P <0.05),the SOD activities of the lenses were decreased( P <0.01) significantly in SC group as compared with that in the control group.The plasma MDA contents were increased( P <0.01),the erythrocyte SOD activities were decreased( P <0.01) significantly in the SC group,as compared with that in the control group.Conclusion The increasing lipid peroxidation lesion induced by free radical and the decreasing antiperoxidation ability were closely related to SC.The peroxidation lesion of lens and the decreasing of antiperoxidation ability was probably resulted from the decreasing of antiperoxidation enzyme activities in whole.
出处
《眼科新进展》
CAS
2000年第2期124-125,共2页
Recent Advances in Ophthalmology
关键词
老年人
白内障
丙二醛
超乳化物歧化酶
senile cataract
lens
malondialdehyde
superoxide dismutase
