摘要
[目的]探讨中药成份复方(丹参酚酸B、山楂黄酮)对大鼠非酒精性脂肪性肝病相关因素的影响。[方法]大鼠被随机分为:①正常对照组,普通鼠饲料喂养;②模型组,高脂饲料喂养;③中药预防组,高脂饲料喂养的同时加每天1次灌服丹参酚酸B(200mg/kg)和山楂黄酮(40mg/kg);④中药治疗组,高脂饲料喂养4周后加每天1次灌服丹参酚酸B(200mg/kg)和山楂黄酮(40mg/kg);⑤西药组:高脂饲料喂养4周后加每天1次灌服二甲双胍片(0.5g/kg)。实验共12周。[结果]①12周时中药预防组大鼠血清脂联素含量较模型组显著升高(P<0.01);②各组大鼠血清游离脂肪酸和肿瘤坏死因子-α含量比较差异无统计学意义;③与模型组相比,6、8、12周时,中药预防组和中药治疗组大鼠肝组织三酰甘油含量明显降低(P<0.01)。[结论]丹参酚酸B和山楂黄酮联用对大鼠非酒精性脂肪性肝病相关因素具有干预作用。
[Objective]To assess the effectiveness of Salvianolic acid B and Hawthorn flavone on nonalcohol fatty liver disease related factors in rats. [Methods]The rats were randomly divided into five groups ： ①control group fed with standard chow. ②model group fed with a high-fat diet. ③Chinese medicine prophylases group fed with a high-fat diet plus Salvianolic acid B（200 mg/kg） and Hawthorn flavone（40 mg/kg）orally once a day. ④Chinese medicine treatment group, in which rats were fed with a high-fat diet for 4 weeks,and then Salvianolic acid B（200 mg/kg）and Hawthorn flavone（40 mg/kg）were orally given once a day. @western medicine treatment group, in which rats were fed with a high-fat diet for 4 weeks,Metformin Tablets（0.5 g/kg）were added orally once a day for total 12 weeks. [Results] ① The sera level of adiponectin was significantly higher in Chinese medicine prophylases group than model group after 12-week-treatment （P~ 0.01）. （~） No difference was found in the sera level of free fatty acids（FFA）and tumor necrosis factor-α（TNF-α） in all groups at any time. ② Comparing with model group, triglyceride （TG）in rats liver of Chinese medicine prophylases group or Chinese medicine treatment group notably reduced in 6,8,12 weeks. [Conclusion]Salvianolic acid B and Hawthorn flavone have the effect on nonalcohol fatty liver disease related factors.
出处
《中国中西医结合消化杂志》
CAS
2012年第6期245-248,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
上海市卫生局课题(No:2008219)
