摘要
目的:用接受器工作特性(ROC)曲线分析评价超声形态积分(SMS)及CA125对卵巢肿瘤的诊断价值。方法:回顾性分析105例住院患者手术、超声等临床资料,术前计算SMS,检测血清CA125;SMS范围1～10,由肿瘤体积积分和结构积分组成。与术后病理对照,绘制ROC曲线,确定最佳截断值。结果:ROC结果显示,SMS诊断卵巢肿瘤的ROC曲线下面积为0.866,CA125诊断卵巢肿瘤的ROC曲线下面积为0.878,z=0.52,P>0.05。以5为截断值,SMS诊断卵巢肿瘤的敏感性88.06%,特异性68.42%,阳性预测值83.10%,阴性预测值76.47%;以35U/mL为截断值,CA125诊断卵巢肿瘤的敏感性85.07%,特异性71.05%,阳性预测值83.82%,阴性预测值72.94%。结论:SMS与CA125诊断卵巢肿瘤的ROC曲线下面积差异无统计学意义,两者均是诊断卵巢肿瘤的有效方法。
OBJECTIVE： To determine the efficacy of sonographic morphology scores （SMS） and CA125 test to diagnose ovarian tumors by receiver operating characteristic （ROC） curve. METHODS： Preoperative data including ultra- sound and blood assays in 105 patients with ovarian tumors were assessed using SMS-a score of 1 to 10 based on volume and morphologie complexity and CA125 level tested. The final diagnosis was based on the pathological findings. The ROC curve was drawn to determine the optimum cut-off value. RESULTS： Area under the ROC curve of SMS for ovarian tumors was 0. 866,and area under the ROC curve of CA125 was 0. 878. By z test,there was no significant difference be- tween SMS and CA125 in the diagnosis of ovarian tumors （z= 0.52, P〉0.05）. With a cut-off value of 5, the sensitivity, speeifieity,PPV,and NPV of SMS were 88.06%, 68.42%, 83.10% and 76.47% respectively. With a cut-off value of 35 U/mL,the sensitivity,specifieity,PPV,and NPV of CA125 were 85.07% ,71.15% ,83.82% and 72.94% respectively. CONCLUSION： The sonographic morphology scores,as well as CA125 test,is an accurate and simple method to diag- nose ovarian tumor due to no significant difference in their area under the ROC curve.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第11期863-866,共4页
Chinese Journal of Cancer Prevention and Treatment
