摘要
目的 :为明确标记抗体引入体内有可能给机体带来的毒副作用。 方法 :采用放射性核素Tc 99M ,以环DTPA方法标记抗CEA单克隆抗体 ,对标记抗体的体内药物代谢动力学进行初步探讨。 结果 :标记抗体为无菌、无热源、无毒性 ,其体外标记方法简单 ,同时具有很高的标记率。 结论 :标记抗体临床使用安全 ,其血循环中存留时间较长 ,以及肝脏的高浓度应是其体内分布特点。
To study the toxicity and side effect of labelled antibodies injected into body.Methods:CEA monoclonal antibodies were labelled with Tc 99m by cyclic DTPA method,and their pharmacokinetics in vivo were investigated.Results:The antibodies were free of bacteria,pyogen and toxicity.The labelling method was simple and of high labelling ratio.Conclusion:The labelled antibodies were safe in clinical application,the characteristics of their bio distribution in body were long time lasting in blood circulation and high concentration in liver.
出处
《中国中西医结合外科杂志》
CAS
2000年第2期121-122,共2页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
