摘要
目的 :本文以大承气汤对烫伤后大鼠休克期肠道细菌移位抑制作用进行实验研究。 方法 :采用Wister大鼠 40只 ,分为 4组 ,(1)正常对照组 ,10只 ;(2 )烫伤后不灌药组 ,10只 ;(3)烫伤后灌入生理盐水组 ,10只 ;(4)烫伤后灌入大承气汤组 ,10只。 72h后取肝、脾、肾脏和盲肠进行细菌培养和菌落计数。 结果 :烫伤后休克期灌大承气汤组 ,肝、脾、肾等组织中未发现细菌生长 ,而烫伤后不灌药组肝、脾、肾等组织中检验出肠道内常居菌 ,两组间对照差异显著 (P <0 .0 5 ) ,烫伤后灌盐水组肝、脾、肾、盲肠细菌培养阴性率为 40 % ,烫伤后不灌药组细菌培养阳性率为 47%。 结论 :严重烫伤早期应用大承气汤 ,可能产生对肠道细菌抑制的作用 ,进一步研究该方剂在烧伤领域中的作用 ,可能为临床应用奠定理论基础。
To introduce the adoption of Da Cheng Qi Tang to inhibit the bacteria translocation in the intestines of burned rats during their shock.Methods:40 Wister rats were divided into four groups (1)Normal group,10 rats;(2)Burn without treatment group,10 rats;(3)Burn with N.S treatment group,10 rats;(4)Burn with Da Cheng Qi Tang treatment group.After rats were injured by boiling water for 72 hours,the sample of liver,spleen,and kidney were collected for microbiological culture.Results:The group of burned rats treated with Da Cheng Qi Tang during their shock showed great difference with the group that was not treated with Da Cheng Qi Tang.( P<0.05 ).With the group which had been treated with the physiological saline the culture of bacteria in liver,spleen,kidney and blind intestines showed(+)by 40%,the group without treatment,the culture of bacteria showed(+)by 47%.Conclusion:As a result,the Da Cheng Qi Tang possessed a powerful role of inhibition on translocation of intestinal bacteria in severe bum rats.The experiment proved the early adoption of Da Cheng Qi Tang in treatment of severe burns could bring about the inhibition of bacteria translocation in the intestines.Further investigation of Da Cheng Qi Tang in the field of burns might eventually establish the theoretical basis for the clinical application.
出处
《中国中西医结合外科杂志》
CAS
2000年第2期86-87,共2页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
