摘要
采用鼠须聚已烯醇栓线栓塞大鼠大脑中动脉 ,观察缺血 1、1 .5、2、3、4、6、9、1 2及 2 4h后 2 %红四氮唑 (TTC)标记的梗死体积 ,并与时间进行了相关分析。结果表明缺血 1h组及 90min组TTC染色未发现梗死灶 ,缺血 2h大鼠基底节区出现梗死灶 ,边界欠清。 4h缺血动物梗死体积明显增大 ,和 2、3h组比较差异已有显著性意义 (P <0 .0 1 )。各组动物随缺血时间梗死体积渐趋增大 ,与时间有显著相关性 (r =0 .86 ,P =0 .0 0 2 )。至 1 2h梗死体积渐趋稳定 ,与 2 4h点相比差异无显著性意义 ,但 2 4h组动物死亡率高。该研究为扩大治疗时间窗的保护性治疗提供了理论依据。
To explore the correlation between time and infarct volume in permanant intraluminal occlusion of middle cerebral artery model in rats, we induced focal cerebral ischemia in 54 male Wistar ratsby intraluminal occlusion of middle cerebral artery for 1, 1.5, 2, 3, 4, 6, 9, 12 and 24 hours respectively. The correlationbetween time and infarct volume analyzed.The infarct lesion was initially found at 2 hours of ischemia, mainly located in the striatum, and then evoluted until 12 hours of ischemia. There was a significantly positive correlation between time and infarct volume (r=0.86,P=0.002). Twenty four hours ischemia induced a relative higher mortality than 12 hours, but the infarct volume between two groups was not significant.We concluded that there is a time course of infarct volume in intraluminal occlusion of middle cerebral artery model in rats.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2000年第2期123-124,共2页
Medical Journal of Chinese People's Liberation Army
关键词
脑缺血
时间
体积
大鼠
脑梗塞
cerebral ischemia
time
infarct
volume
rat
