摘要
目的探讨无创呼吸机联合泰能治疗慢性阻塞性肺疾病（COPD）合并肺性脑病患者的临床疗效。方法选择高州市第二人民医院2008年11月至2010年11月COPD合并肺性脑病患者70例，将以上患者随机分为观察组和对照组。两组患者均给予祛痰、解痉、糖皮质激素类药物治疗及根据患者病情给予强心剂、利尿剂等。对照组同时给予泰能，每天2—4g，连续应用5—7d。观察组在对照组治疗基础上实施无创正压通气治疗。观察两组患者治疗72h后心率、呼吸频率、动脉血气指标改变情况；记录两组患者意识改善情况。结果观察组治疗后呼吸、心率、pH值、氧分压、二氧化碳分压分别与对照组治疗后比较，差异有统计学意义（P〈0．05）；两组患者意识障碍改善时间和意识障碍消失时间比较差异有统计学意义（P〈0．05）。结论无创呼吸机联合泰能能够显著改善COPD合并肺性脑病患者的临床症状，临床效果显著，值得借鉴。
Objective To investigate the clinical efficacy of noninvasive ventilator combined with imipenem on patients with COPD complicated with pulmonary encephalopathy. Methods Seventy cases of COPD complicated with pulmonary encephalopathy were selected from November 2008 to November 2010, and were randomly divided into observation group and control group. Expectorant, spasmolysis, local anesthetic drugs, cardio tonic, diuretic were given to the patients in the two groups. Imipenem was used in control group, 2 -4 g/day, the course was 5 -7 days. Noninvasive positive pressure ventilation and imipenem were used in observation group. The heart rate, respiratory rate, arterial blood gas analysis were observed at 72 h after treatment. Results There were significant differences in the value of heart rate, respiratory rate, pH, PaO2, PCO2 between the two groups （P 〈 0. 05）. There were significant differences in the improvement and disappearance of disturbance of consciousness between the twogroups （ P Noninvasive 〈 0. 05 ）. Conclusions ventilator combined with imipenemcan improve the clinical symptoms of COPD complicated with Ful,,aonary encephalopathy, the clinical efficacy is significant.
出处
《中国实用医刊》
2012年第14期46-47,共2页
Chinese Journal of Practical Medicine
关键词
慢性阻塞性肺病
无创通气
泰能
Chronic obstructive pulmonary disease
Noninvasive ventilator
Imipenem
