摘要
随着新辅料、新技术、新载体的不断涌现,鬼臼毒素及其衍生物的新剂型的研究呈现出广阔的前景。概述了鬼臼毒素在脂质体纳米粒、层状双氢氧物、聚合物胶束等新型载药系统中对多种肿瘤细胞的抗肿瘤作用;同时介绍了鬼臼毒素衍生物依托泊苷微球、口服微乳、纳米脂质体、β-环糊精包合物等新剂型在抗肿瘤研究中的靶向治疗、增加疏水性药物的溶解度、缓释作用方面的应用。随着鬼臼毒素及其衍生物的新型靶向制剂的进一步研究,可在降低毒副作用的同时增强其抗肿瘤作用,为合理开发鬼臼毒素及其衍生物的新剂型提供了研究基础。
With the new materials, new technologies and new emerging carriers, the research of novel dosage form of podophyllotoxin and its derivatives is opening up a broader prospect. Relevant literatures are collected, compiled for review. The applications of podophyllotoxin in liposome nanoparticles, layered double hydroxide, drug-loaded polymer micelles, and other new drug carrier system and its anti-tumor effect were introduced. The podophyllotoxin derivatives etoposide microspheres, oral microemulsion, nano-liposomes, β- cyclodextrin and other new formulations for anti-cancer in targeted therapy, increasing the solubility of hydrophobic drugs, sustained-release effect of the drug were also introduced. Further studies on podophyllotoxin and its derivatives as novel targeted agents will reduce toxicity and enhance the characteristics of anti-tumor effect. All these could serve as referential basis for the reasonable development of podophyllotoxin and its derivatives with new formulations.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第13期296-299,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
浙江省自然科学基金(Y2081030)
嘉兴市科技计划项目(2009AY2066)
关键词
鬼臼毒素
依托泊苷
新剂型
抗肿瘤
podophyllotoxin
etoposide
new preparations
anti-tumor
