摘要
目的:制备芦丁铋二元配合物微囊,并对其进行质量评价。方法:利用自制的芦丁铋二元配合物为原料,采用复凝聚法制备芦丁铋二元配合物微囊,通过正交设计优选其制备工艺;通过包封率、验证性试验、粒径检查等对其进行质量评价。结果:芦丁铋二元配合物微囊最佳制备条件为囊材与囊心物的质量比6:1,成囊pH 3.5,成囊温度60℃,固化时间1.5 h。结论:应用优选工艺制备的微囊,其包封率>40%,重复性好,90%微囊粒径在15～85μm。
Objective： To prepare binary complexes of rutin and bismuth microcapsules, and evaluate its quality. Method： With homemade binary complexes of rutin and bismuth as raw material, binary complexes of rutin and bismuth microcapsules was prepared by complex coacervation method, preparation technology was optimized by orthogonal test; Quality evaluation was finished by detecting encapsulation efficiency, verification test and particle size. Result： Optimum preparation condition of binary complexes of rutin and bismuth microcapsules was： capsule material-capsule core 6 ： 1, encysted pH 3.5, capsule temperature 60 ℃ , curing time 1.5 h. Conclusion： Applying optimized technology to prepare microcapsules, encapsulation efficiency was more than 40% with good reproducibility, and particle size of 90% microcapsules was 15-85 μm.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第13期31-33,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
湖南省自然科学基金项目(11JJ5058)
国家自然科学基金项目(20973145/B0309)
湖南省科技计划项目(2011TP4016-2)
关键词
芦丁铋二元配合物
微囊
制备
质量评价
binary complexes of rutin and bismuth
microcapsules
preparation
quality evaluation
