摘要
目的:研究健脾清化方对慢性肾脏疾病(CKD)2～3期脾虚湿热患者慢性微炎症状态的作用。方法:3个中心的随机对照临床研究,随机分成中药组和对照组,并设20例健康体检患者为正常组。对照组予西医常规治疗,中药组在对照组基础上加用健脾清化方。共随访8周,观察治疗前后血肌酐(Scr)、超敏C反应蛋白(hs-CRP)、白细胞介素-17(IL-17)、干扰素-γ(IFN-γ)的变化。结果:最终中药组有74例、对照组有73例完成研究。治疗前两组的hs-CRP、IL-17、IFN-γ比正常组显著升高(P<0.05)。8周的治疗后,中药组的Scr有显著下降(P<0.05)。中药组hs-CRP平均下降了26.4%(P<0.05),而对照组有上升的趋势。中药组IL-17平均下降了73.5%(P<0.05),对照组平均下降了25.6%。中药组IFN-γ平均下降了48.3%(P<0.05),而对照组平均下降了23.3%。结论:CKD2～3期的脾虚湿热患者存在慢性微炎症状态,健脾清化方能明显改善微炎症状态。
Objective：To study the effects of＂Jian Pi Qing Hua Decoction＂on microinflammatory state in patiente of syndrome of dampness-heat due to spleen deficiency in CKD2 ～ 3.Methods：Randomized control clinical study of three centrals,the patients were divided into traditional Chinese drug group and control group,and 20 normal persons as normal group.Patients in normal group were accept conventional therapy of modern medicine,and the patients in traditional Chinese drug group were plus ＂Jian Pi Qing Hua Decoction＂.The concentration of Scr,hs-CRP,IL-17,and IFN-γ were tested before and after treatment by 8 weeks.Results：There were 74 patients in traditional Chinese drug group and 73 patients in control group.The concentration of hs-CRP,IL-17 and IFN-γ of all patients were significantly increased than normal group（P 〈 0.05）.The concentration of Scr in traditional Chinese drug group was significantly decreased after treatment（P 〈 0.05）.The concentration of hs-CRP was significantly decreased 26.4% after treatment in traditional Chinese drug group（P 〈0.05）,and that in control group was increased.The concentration of IL 17 was significantly decreased 73.5% after treatment in traditional Chinese drug group（P 〈 0.05）,and that in control group was decreased 25.6%.The concentration of IFN-γ was significantly decreased 48.3% after treatment in traditional Chinese drug group（P 〈0.05）,and that in control group was decreased 23.3%.Conclusion：Microinflammatory state was existed in patientes of syndrome of dampness-heat due to spleen deficiency in CKD2 ～ 3.＂Jian Pi Qing Hua Decoction＂can improve microinflammatory state in theses patients.
出处
《中国中西医结合肾病杂志》
2012年第6期504-506,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
国家自然基金资助项目(No.81173219)
上海市教育委员会E-研究院建设计划项目(No.E03008)
上海市高校创新团队建设项目
上海市科委创新行动计划项目(No.11DZ1973100)
上海市浦东新区社会发展局卫生科技项目(No.PW2008D-4)
关键词
脾虚湿热
健脾清化方
微炎症状态
慢性肾衰竭
Syndrome of dampnessheat due to sleep deficiency Jianpi qinghua decoction Microinflammatory state Chronic renal failure
