摘要
目的观察他汀类药物对缺血性脑卒中复发的预防作用。方法观察100例动脉粥样硬化性脑梗死患者,随机分为常规组与治疗组,每组50例。治疗组在常规组治疗基础上加用他汀药物治疗,治疗2周后比较两组患者的TC、LDL-C、HDL-C、hs-CRP水平及神经功能缺损评分。结果常规组与治疗组两组在治疗前TC、LDL-C、HDL-C、hs-CRP、NHSS水平差异均无统计学意义(P>0.05);治疗2周后,两组血清TC、LDL-C、hs-CRP、NHSS水平均较治疗前下降,HDL-C均较治疗前上升。阿托伐他汀钙片治疗组较常规组TC、LDL-C、HDL-C、hs-CRP、NHSS下降明显,HDL-C升高显著,差异有统计学意义(P<0.05)。结论他汀类药物能有效降低脑卒中血脂水平,控制炎症,从而改善患者神经功能。
Objective To observe the effects of statin on the treatment of cerebral infarction. Methods 100 patients were divided into two groups,normal group received normal treatment and atorvastatin group were added 10 mg atorvastatin in every day based on normal treatment for 2 weeks.Serum concentration of cholesterol,hs-CRP,the scores of National Institutes of Health Stroke Scale were measured one day after admission and at 2 weeks. Results The serum concentrations of TC,LDL-C decreased significantly in atorvastatin group after 2 weeks treatment （P 〈 0.05）,and the serum concentration of HDL-C increased significantly（P 〈 0.05）.There is significant difference in the scores of National Institutes of Health Stroke Scale after 2 weeks treatment（P 〈 0.05）. Conclusion Statin could effectively reduce the lipid levels,control inflammation,thus to improve the patient neural function.
出处
《中国医药科学》
2012年第10期49-50,共2页
China Medicine And Pharmacy
关键词
他汀
缺血性脑卒中
复发
Statin
Cerebral infarction
Recurrent
