摘要
目的:研究SLP-2基因在胃腺癌及正常胃黏膜中的表达情况.方法:应用免疫组织化学法及RT-PCR法分别检测45例及40例胃腺癌及其癌旁正常胃黏膜中SLP-2基因的表达,并结合免疫组织化学结果及胃癌患者的临床病理资料进行分析.结果:免疫组织化学和RT-PCR结果均显示SLP-2在胃腺癌组织中的表达高于正常配对胃黏膜(68.9%vs26.7%,1.12±0.47vs0.63±0.31,均P<0.01),且SLP-2的表达与胃癌TNM分期及有无淋巴结转移相关(2=5.32、4.78,均P<0.05).结论:SLP-2基因在胃腺癌组织中高表达,可能参与胃腺癌的发生发展和转移.
AIM： To investigate the expression of stomatin- like protein 2 （SLP-2） in gastric adenocarcinoma and to analyze its significance. METHODS： The expression of SLP-2 mRNA and protein was detected by RT-PCR in 40 cases and by immunohistochemistry in 45 cases of human gastric adenocarcinoma and adjacent tumor-free tissue, respectively. The relationship between SLP-2 expression and clinicopathologic char- acteristics of gastric adenocarcinoma was then analyzed. RESULTS： The expression of SLP-2 mRNA and protein in gastric adenocarcinoma was signifi- cantly higher than that in adjacent tumor-free tissue （68.9% vs 26.7%, 1.12± 0.47 vs 0.63 ± 0.31, both P 〈 0.01）. SLP-2 expression in gastric ad- enocarcinoma was associated with lymph node metastasis and TNM stage （χ^2 = 5.32, 4.78, both P 〈 0.05）, but not with other clinicopathologic characteristics （all P 〉 0.05）. CONCLUSION： The expression of SLP-2 is in- creased in gastric adenocarcinoma. SLP-2 may play important roles in the occurrence, develop- ment and metastasis of gastric adenocarcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第19期1778-1781,共4页
World Chinese Journal of Digestology
关键词
胃腺癌
SLP-2
TNM分期
淋巴结转移
Gastric adenocarcinoma
Stomatin-like protein 2
TNM staging
Lymph node metastasis
