摘要
克罗恩病(Crohn's disease,CD)是发生在消化系的原因不明的慢性复发性炎症疾病,其病因和发病机制可能与肠道异常免疫应答、肠道微生态调节异常、肠黏膜屏障缺损、持续肠道感染等有关.对CD的药物治疗决策原则上建立在疾病的进展程度、病变累及范围、合并症以及术后状态等,目的是控制临床症状,诱导缓解,促使内镜下黏膜愈合,恢复肠道生理功能,延缓手术治疗,预防复发和致残出现.本文重点阐述当前对CD患者的药物治疗方案以及新的治疗措施.
Crohn＇s disease （CD） is a chronic inflammatory disease of the digestive tract. Its etiology and pathogenesis are still elusive. Abnormal intes- tinal immune response, dysregulation of intes- tinal microflora, defects of intestinal mucosal barrier, and persistent intestinal infection may be involved in the pathogenesis of this disease. Therapeutic strategies should be typically based on disease severity, affected extent, complica- tions, and postoperative status. The therapeutic purposes are to control the clinical symptoms, induce remission, enhance endoscopic mucosal healing, restore intestinal physiological function, postpone surgical intervention, and prevent postoperative recurrence and disability. This paper highlights current strategies and novel ap- proaches for medical therapy in CD patients.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第19期1701-1704,共4页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30971358
No.81061120521
关键词
克罗恩病
药物治疗
规范化
Crohn＇s disease
Medical therapy
Standardization
