摘要
胆固醇7-羟化酶(cholesterol 7-alpha hydroxy-lase,CYP7A1)是胆汁酸合成代谢经典途径的限速酶.其表达不仅具有昼夜节律,而且可由基因多态性、饮食、激素、细胞因子及药物等多种因素调节.CYP7A1的基因多态性与疾病及对药物的治疗反应存在相关性,同时多种核受体参与了CYP7A1的表达的调控,共同组成了转录激活/抑制级联网络,维持体内胆汁酸合成及脂质动态平衡.本文主要对CYP7A1表达、调控及与疾病及治疗反应的相关性等方面的研究进行综述.
Cholesterol 7-alpha hydroxylase （CYP7A1） is the first and rate-limiting enzyme in the neutral pathway of bile acids synthesis. The expression of CYP7A1 can be regulated not only by diurnal rhythm, but also by gene polymorphism, diet, hormones, cytokines and drugs. CYP7A1 gene polymorphism is associated not only with some diseases but also with response to drug therapy. A cascade network consisting of multiple nuclear receptors is involved in the regulation of CYP7A1 expression to control bile acid synthesis and lipid metabolism.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第16期1439-1446,共8页
World Chinese Journal of Digestology
关键词
胆固醇7-羟化酶
基因多态性
昼夜节律
核受体
Cholesterol 7-alpha hydroxylase； Gene polymorphism； Diurnal rhythm； Nuclear receptor
