摘要
目的:分析心脏外科围手术期发生12例急性药物性肝损伤的临床特点及治疗效果.方法:回顾分析2009-2011年桂林医学院附属医院围手术期发生急性药物性肝损伤的12例心脏外科患者的临床表现、治疗情况及预后.结果:引起药物性肝损害的药物主要是抗生素、抗结核药物.主要临床表现是黄疸9例(82%),化验肝功能发现明显异常3例(18%).心脏手术前出现9例,手术后出现3例.其中2例为缩窄性心包炎,7例为感染性心内膜炎,冠状动脉粥样硬化性心脏病2例,风湿性心脏病1例.12例患者均治愈出院.随访6-44mo,10例有随访应答,复查肝功能正常,无中期并发症.结论:心脏外科围手术期急性药物性肝损伤多发生于右心功能不全、营养差的患者.对心脏手术前药物致肝损伤的早期诊断和及时合理的治疗,可以使患者的肝功能恢复正常,帮助患者度过围手术期,预后良好.
AIM：To explore the clinical characteristics and treatment of drug-induced liver injury in the perioperative period of cardiac surgery.METHODS：The clinical data for 12 patients with drug-induced liver injury who were treated from 2009 to 2011 at the Affiliated Hospital of Guilin Medical College were collected.The clinical characteristics and treatment of drug-induced liver injury in the perioperative period of cardiac surgery were retrospectively analyzed.RESULTS：The disease had clear causes in all patients.The main factors inducing druginduced liver injury include antibiotics and antituberculosis drugs.The clinical manifestations mainly include jaundice（9 cases） and increasedbilirubin and serum enzymes（3 cases）.The disease categories comprised infective endocarditis（IE,7 cases）,constrictive pericarditis（CP,2 cases）,coronary heart disease（CHD,2 cases） and rheumatic heart disease（RHD,1 case）.All patients were cured and discharged from hospital.No complications occurred in 10 patients evaluable at follow-up.CONCLUSION：The patients with congestive heart failure may tend to develop drug-induced liver injury.Early and accurate diagnosis is important for the treatment and prognosis of druginduced liver injury.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第15期1350-1353,共4页
World Chinese Journal of Digestology
关键词
心脏手术
药物性肝损伤
围手术期
Open heart surgery
Drug-induced liver injury
Perioperative period
