摘要
目的探讨丙泊酚中/长链脂肪乳镇静对机械通气下腹内压升高患者呼吸力学的影响。方法将48例机械通气下腹内压升高患者随机分为丙泊酚中/长链脂肪乳镇静组(观察组)和咪达唑仑镇静组(对照组),每组24例。观察两组患者镇静后呼吸力学、氧合指数及腹内压的变化。结果两组患者镇静后比较,肺顺应性、氧合指数的差异均无统计学意义(均P>0.05),观察组气道阻力及腹内压均较对照组明显降低(均P<0.05)。结论在机械通气患者中使用丙泊酚中/长链脂肪乳镇静有助于改善腹内压升高患者的呼吸力学,同时对腹内高压有一定的缓解作用。
Objective To observe the effect of propofol on breathing mechanics in critical patients with mechanical ventilation and intra-abdom inal hypertension （IAH）. Methods Fourty-eight IAH pa- tients in ICU, who were treated by mechanical ventilation, were randomly divided into 2 groups： the ob- servation group and the control group. Propofol was used for the observation group, and midazolan was used for the control group, there were 24 cases for each group. The changes of breathing mechanics and oxygenation indexes and intra-abdominal pressure were observed during sedation. Results There was a significant decrease in airway resistance and intra-abdominal pressure （P 〈 0.05 ）, but there was no sig- nificant difference in pulmonary static conpliance and oxygenation indexes between the two groups （ all P 〉 0.05）. Conclusion Using propofol in patients,who were treated by mechanical ventilation ,is better in reducing mechanical ventilation of airway resistance and improving breathing mechanics and lessening in- tra-abdominal pressure.
出处
《苏州大学学报（医学版）》
CAS
2012年第3期407-409,435,共4页
Suzhou University Journal of Medical Science
关键词
丙泊酚
机械通气
腹内高压
呼吸力学
氧合指数
propofol
mechanical ventilation
intra-abdom inal hypertension
breathing mechanics
oxygenation indexes
