摘要
目的 了解恶性梗黄疸患者细胞免疫功能被抑制状况及减黄术前后的变化。方法 应用单向免疫扩散法和酶联免疫吸附法动态监测 6 0例恶性梗黄疸患者围减黄手术期外周血免疫抑制酸性蛋白 (IAP)和可溶性白介素 受体 (SIL- 2 R)水平的变化并与同期 2 5例良性梗阻性黄疸患者及 40例正常人进行比较。结果 恶性梗黄疸患者血清 IAP和 SIL- 2 R水平术前 1天、术后 10天及 2 0天明显高于良性梗黄疸患者及正常人 (P<0 .0 1) ;良、恶性梗黄疸患者因手术创伤术后短期 IAP和 SIL- 2 R水平呈一过性增高 ,随病情的恢复和黄疸的减退 ,IAP和 SIL- 2 R水平逐渐下降 ,术后 2 0天良性梗阻性黄疸患者与正常人相比无显著性差异 (P>0 .0 5 ) ,恶性梗黄患者仍处于较高水平。结论 恶性梗黄患者外周血中免疫抑制物 IAP和 SIL- 2 R明显增高 ,患者的细胞免疫功能受到明显抑制而低下 ,减黄术可不同程度地改善患者的免疫功能。
Objective IAP and SIL-2R are important immunologic suppressive factors.Methods The IAP and SIL-2R level were studied dynamically by single immunodiffusion and ELISA test in perioperal blood from 60-case with Malignant obstructive Jaundice(MOJ),and compared with Benign Obstructive Jaundice(BOJ) in 25 cases and 40 normal cases.Result The level of IAP and SIL-2R in MOJ were obviously higher than that of BOJ and normal control before and after operation(P<0.01),the level of IAP and SIL-2R in obstructive jaundice increased gradually in short time after operation and decreased slowly in recovery time.Fourteen days after operation,the serum IAP and SIL-2R level were no significantly different between BOJ and health groups(P>0.05)and it was higher in MOJ.Condusion The serum level of IAP and SIL-2R increased obviously and the cellular immunologic function was inhilbited in patients with MOJ.The patients immunologic function could be improved after operation.
出处
《肝胆外科杂志》
2000年第1期37-39,共3页
Journal of Hepatobiliary Surgery
