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2型糖尿病患者血清脂联素水平及颈动脉内膜中层厚度与应用阿托伐他汀的关系 被引量:3

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摘要 目的:2型糖尿病患者血清脂联素水平及颈动脉内膜中层厚度与应用阿托伐他汀的关系。方法:将我院在2010年1月至2011年10月期间收治的63例2型糖尿病患者分为两组,实验组31例,采用阿托伐他汀进行治疗;对照组32例,不采用阿托伐他汀药物。比较两组治疗前后颈动脉内膜中层厚度(IMT)和脂联素(APN)、超敏C-反应蛋白(hs-CRP)和白细胞介素-6(IL-6)浓度变化。结果:治疗后实验组的IMT显著降低,而对照组的无变化;斑块检出率方面,实验组由治疗前的51.61%下降至29.03%,而对照组的斑块检出率由53.12%上升至59.37%,具有统计学意义,P均<0.05;治疗后,实验组的APN浓度显著提高,hs-CRP和IL-6的浓度显著下降;对照组无明显变化。两组的差异具有统计学意义,P<0.05。结论:采用阿托伐他汀治疗2型糖尿病,可以显著减少颈动脉内膜中层的厚度,并且增加血清中脂联素的浓度,值得在临床中推广。
作者 陈春莲
出处 《河北医学》 CAS 2012年第7期953-954,共2页 Hebei Medicine
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