摘要
目的探讨杞菊地黄丸治疗干眼症的效果。方法 2010年1月—2010年6月在PCO(Pennsylvania College of Optometry)眼科医院就诊的干眼症患者120例(240只眼),均以干眼为主诉,年龄45～72岁,身体健康无其他眼疾,无吸烟史,无接触镜佩戴史。所有患者的McMonnies DEQ(McMonnies DryEye Questionnaire)量表评分为阳性,辨证为肝肾阴虚。随机分为杞菊地黄丸组和人工泪液组,各60例。分别予口服杞菊地黄丸,局部羧甲基纤维素钠滴眼液(Refresh Plus滴眼液)点眼,均治疗30 d。比较2组患者的治疗效果。结果1.泪液分泌试验(Schirmer I test,SIt):杞菊地黄丸组(14.27±1.41)mm/5 mins,人工泪液组(12.55±1.37)mm/5 mins(Z=-4.573,P=0.0000)。2.泪膜破裂时间(tear break-up time,TBUT):杞菊地黄丸组(18.07±3.58)s,人工泪液组(13.38±3.17)s(t=7.578,P=0.0000)。3.总有效率:杞菊地黄丸组96.70%,人工泪液组86.7%(Z=-3.310,P=0.001)。4.西医临床积分:杞菊地黄丸组6.27±3.27,人工泪液组9.47±3.57(Z=-4.87,P=0.000)。5.中医症状积分:杞菊地黄丸组3.10±1.398,人工泪液组3.81±1.387(Z=-2.370,P=0.018)。结论杞菊地黄丸治疗干眼症有效;除了西医常规的人工泪液外,也可以考虑使用相关的中医方法治疗干眼症。
[Abstract] OBJECTIVE To evaluate the efficiency of TCM herbal medicine Qiju Dihuang Pills in treating dry eye,and compare to the western standard methods. METHODS A total of 120 age and gender matched subjects were divided into 2 groups, 60 TCM group （The Study Group） and 60 Western Group （The Control Group）. All came with dry eyes as their chief complains,and aged 45-72 years old were recruited. All subjects had good general health ,no ocular disease ,not smoking and were non-contact lens wearer. Inclusion criteria of dry eye subjects were either a positive score in the McMonnies Dry Eye Questionnaire （DEQ） or having symptoms associated with dry eyes. The study group （TCM Group） of 60 patients were given Qiju Dihuang Pills orally and the control group （Western Group ）of 60 patients were given Refresh Plus to be instilled locally, both groups were put on 30 days treatment. The absolute and the relative measurements of the anterior ocular surface were analysed in pre and post treatments in TCM group （The Study Group） or western group （The Control Group）. RESULTS Mean＋SD SIT （Schirmer＇ s Test） was 14.27±1.41mm/5 mins in TCM group and 12.55±1.37 mm/5 mins in control group （P=0.000 0）. Mean TBUT （Tear Break-Up Time） was 18.07±3.58 seconds in TCM group and 13.38± 3.17 in control group （P=0.000 0）. Significant differences were found in mean SIT and mean TBUT between the TCM and Western control group over a period of 30 days of treatment. Total efficacy percentage in improvement was 96.7% in TCM group and 86.67% in control group （P=0.001）. The western evaluation scores in TCM dry eye group had decreased at a lower score （6.27±3.27） as compared to the western control group （9.47±3.57） and the result was significant （P=0.000） while the TCM evaluation scores had shown same that the TCM group was 3.10±1.398 in TCM dry eye group and 3.81±1.387 scores in western control group and the result was significant （P=0.018）. CONCLUSIONS The findings demonstratethe usefulness of TCM herbal medicine treatment in treating the commonly seen dry eye syndrome. Apart from using the western standard treatment ,it is more valuable to take into account the relative and comparableTCM method which is also likely to treat the dry eye syndrome.
出处
《中国中医眼科杂志》
2012年第3期172-175,共4页
China Journal of Chinese Ophthalmology
关键词
杞菊地黄丸
人工泪液
对照比较
干眼症治疗
Qiju Dihuang Pills （TCM herbal medicine）
artificial tears
comparison
dry eye syndrometreatment
