摘要
目的探讨血清基质金属蛋白酶-2(MMP-2)和CA125在子宫内膜癌患者手术前后变化及其临床意义。方法选择来本院就诊的43例手术治疗的子宫内膜癌患者,在手术前后检测血清基质金属蛋白酶-2和CA125变化,及在不同病理分期患者中的变化。结果子宫内膜癌患者血清中MMP-2和CA125水平者明显增高。在子宫内膜癌患者中,手术前血清中MMP-2和CA125水平在Ⅲ期、Ⅳ期比Ⅰ期明显增高,而Ⅱ期与Ⅰ期相比无统计学差异,血清中MMP-2和CA125有逐渐增高的趋势;手术后子宫内膜癌患者血清中CA125水平明显降低,在Ⅲ期和Ⅳ期患者中降低尤为明显;手术前血清中MMP-2和CA125水平在G2、G3期比G1期明显增高,随着病理分级的增高,血清中MMP-2和CA125有逐渐增高的趋势;而在手术后血清中MMP-2和CA125明显降低。结论血清中MMP-2和CA125水平变化与子宫内膜癌患者疗效判定、评价预后、复发的早期诊断具有很高的临床价值。
Objective To evaluate the clinical significance of serum matrix metalloproteinase -2 and CA125 in endometrial cancer patients before and after surgery. Methods 43 cases of surgical treatment of endometrial cancer patients involved in the study. Serum levels of MMP-2 and CA125 were detected in patients before and after surgery. Results The serum CA125 and MMP-2 levels were significantly higher in patients with endometrial cancer. In these patients, phase III and period IV was significantly higher than the phase I, while Phase II and Phase I showed no sig- nificant difference in serum MMP-2 and CA125. After surgery, serum MMP-2 and CA125 in endometrial cancer patients were significantly lower than pre-operative, particularly in phase III and IV. Serum MMP-2 and CA125 levels in G2, G3 ratios significantly higher than in G1 phase in pre-operative patients. Serum MMP-2 and CA125 show an increased trend with the elevated type of the pathology. Serum MMP-2 and CA125 de- creased after surgery. A lymph node metastasis in patients with serum MMP-2 and CA125 levels were significantly increased. Conclusions There is significant clinical value of serum MMP-2 and CA125 levels in endometrial cancer to determine efficacy, evaluating prognosis and early diagnosis.
出处
《浙江创伤外科》
2012年第3期297-299,共3页
Zhejiang Journal of Traumatic Surgery
