摘要
目的探讨盐酸氨溴索注射液静脉滴注,联合硫酸沙丁胺醇、布地奈德雾化吸入辅助治疗慢性阻塞性肺疾病急性加重(AECOPD)的临床疗效。方法将60例AECOPD肺功能损伤分级Ⅱ级患者随机分为治疗组30例,对照组30例。对照组给予吸氧、规范抗感染、解痉平喘祛痰等常规治疗。治疗组在对照组的基础上,予硫酸沙丁胺醇2 ml,布地奈德0.5 ml雾化吸入治疗。两组祛痰药均选用盐酸氨溴索30 mg静脉滴注,3次/d。两组疗程均为7 d,治疗后观察并比较两组的临床疗效、急性呼吸困难缓解时间和平均住院天数。结果治疗后,治疗组显效17例,有效10例,无效3例;对照组显效8例,有效19例,无效3例,两组疗效间差异有统计学意义(u=328.5,P=0.046)。急性呼吸困难缓解时间治疗组少于对照组,差异有统计学意义〔(4.30±1.39)d和(5.73±2.08)d,P<0.05〕,住院天数治疗组也少于对照组,差异有统计学意义〔(8.70±3.17)d和(12.16±3.97)d,P<0.05〕。结论氨溴索静脉滴注联合沙丁胺醇、布地奈德氧雾化吸入辅助治疗AECOPD疗效显著,操作简便,临床症状改善快,能缩短患者的住院时间。
Objective To discuss the clinical effects of ambroxol hydrochloride combined with ventolin and budesonide aerosol inhalation on acute exacerbations of chronic obstructive pulmonary disease（AECOPD）.Methods Sixty AECOPD patients with Ⅱ degree pulmonary function were randomly divided into groups control（n=30,received conventional treatment such as oxygen uptaking,anti-infection drug etc.） and treatment（n=30,given ventolin and Budesonide aerosol inhalation based on conventional）.Both groups were treated with ambroxol,30 mg,iv gtt,3 times/d,7 d.The clinical effects,clinical remission time of acute dyspnea and hospital stay were observed after therapy.Results After treatment,marked effect was noted in 17 cases,effect in 10 and no effect in 3 in treatment group,while 8,19,3 in control group,respectively.The difference was significant（u=328.5,P=0.046）.The clinical remission time of acute dyspnea significantly shorter in treatment group than in control（（4.30±1.39）d vs（5.73±2.08）d,P0.05）,hospital stay significantly shorter（（8.70±3.17）d vs（12.16±3.97）d,P0.05）.Conclusion Intravenous ambroxol hydrochloride combined with ventolin and budesonide aerosol inhalation has marked effects on AECOPD,with short remission time and hospital stay.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第17期1990-1992,共3页
Chinese General Practice
关键词
盐酸氨溴索
硫酸沙丁胺醇
布地奈德
肺疾病
慢性阻塞性
急性发作
治疗结果
Ambroxol hydrochloride
Ventolin
Budesonide
Pulmonary disease
chronic obstructive
Acute exacerbations
Treatment outcome
