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肠道氨基酸及氨基酸转运载体研究进展 被引量:11

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摘要 氨基酸是肠黏膜代谢的能量来源和机体营养物质。氨基酸转运载体是将氨基酸跨膜运输的膜蛋白质。近年来的研究发现氨基酸及其转运蛋白通过调节基因表达和信号转导通路有效地调节细胞内的生理活动,而且氨基酸还是肠道炎症的新型治疗靶点等。本文将围绕近年来氨基酸代谢、氨基酸和氨基酸转运载体在信号转导中的作用、氨基酸抗炎作用及氨基酸转运载体在肠道表达等方面的研究进展进行综述。
出处 《生理科学进展》 CAS CSCD 北大核心 2012年第3期202-206,共5页 Progress in Physiological Sciences
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  • 1Chen LX, Li P, Wang JJ, et al. Catabolism of nutritionally essential amino acids in developing porcine entercytes. Ami- no acids, 2009, 37 : 143 - 152.
  • 2Dai ZL, Wu G, Zhu WY. Amino acid metabolism in intesti- nal bacteria: links between gut ecology and host health.Front Biosci, 2011, 16 : 1768 - 1786.
  • 3Dai ZL, Zhang J, Wu G, et al. Utilization of amino acids by bacteria from the pig small intestine. Amino Acids, 2010, 39 : 1201- 1215.
  • 4Broer S. Amino acid transport across mammalian intestinal and renal epithelia. Physiol Rev, 2008, 88 : 249- 286.
  • 5Gilbert ER, Li H, Emmerson DA, et al. Developmental reg- ulation of nutrient transporter and enzyme mRNA abundance in the small intestine of broilers. Poult Sci, 2007, 86 : 1739 - 1753.
  • 6Wu G. Amino acids : metabolism, functions, and nutrition. Amino Acids, 2009, 37 : 1 - 17.
  • 7Gu L, Gao J, Li Q, et al. Rapamycin reverses NPM-ALK-in- duced glucocorticoid resistance in lymphoid tumor cells by in- hibiting mTOR signaling pathway, enhancing G1 cell cycle arrest and apoptosis. Leukemia, 2008, 22 : 2091 - 2096.
  • 8Jain P, Bhalla US. Signaling logic of activity-triggered den- dritic protein synthesis: an mTOR gate but not a feedback switch. PLoS Comput Biol, 2009, 5 : e1000257.
  • 9Weichhart T, Costantino G, Poglitsch M, et al. The TSC- mTOR signaling pathway regulates the innate inflammatory response. Immunity, 2008, 29 : 565 - 577.
  • 10Conigrave AD, Brown EM. Taste receptors in the gastroin- testinal tract II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology. Am J Physiol Gastrointest Liver Physiol, 2006, 291 : G753- G761.

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