摘要
转铁蛋白受体1广泛分布于中枢神经系统中,作为细胞铁摄取的通道在生物体内发挥着重要的作用。转铁蛋白受体1介导"转铁蛋白-Fe3+"复合体的内吞,将转铁蛋白结合的铁送到细胞内,从而调节细胞的发育和功能。转铁蛋白受体1也转运其他金属离子,如锰、铝、铜。转铁蛋白受体1可以帮助大分子药物顺利通过血脑屏障,并成为中枢神经系统疾病的治疗靶点。本文综述近年来转铁蛋白受体1在神经系统中的分布、调节机制和功能以及其作为药物治疗靶点的应用。这些问题的探讨不但为研究转铁蛋白受体1的功能机制提供了新思路,而且对神经科学的理解有重要的意义。
Transferrin receptor 1 exists widely in central nervous system （CNS）. It is responsible for i-ron transport in vivo and mediates the endocytosis of transferring-iron complex, regulating the cell growth. TfR1 transports other metal ions as well, such as Mn, A1 and Cu. It is proved that TfR1 can help macromolecular drugs to pass through the blood-brain barrier and emerges as a potential therapeutic target of neurological diseases in CNS. This review summarizes recent findings in distribution, function, and roodulatory mechanisms of TfR1 as well as its applications as therapeutic targets in clinical medicine. The investigations on these issues can not only provide new ideas for the research about the mechanism and function of TfR1, but also have profound significance in the understanding of neuroscience.
出处
《生理科学进展》
CAS
CSCD
北大核心
2012年第3期188-192,共5页
Progress in Physiological Sciences
基金
国家重大科学研究计划(2009CB941402)
国家自然科学基金(31070945)资助课题
