摘要
目的:观察不同剂量的曲马多伍用丙泊酚用于无痛人流的效果,筛选出曲马多用于无痛人流的最佳剂量。方法:选择早孕妇女300例,根据所使用曲马多剂量,随机分为5组:Ⅰ组(0mg/kg),Ⅱ组(0.5mg/kg),Ⅲ组(1mg/kg),Ⅳ组(1.5mg/kg)和V组(2.0mg/kg)。各组先予以曲马多组静脉注射,然后以1.5～2.5mg/kg剂量静脉注射丙泊酚;观察患者的镇痛效果、麻醉时间、清醒时间、丙泊酚用药量和副作用等。结果:随着曲马多的用量逐渐增加,镇痛效果逐渐增强,丙泊酚的用量逐渐减少;当曲马多的用量达到1.5mg/kg以上时,镇痛效果趋于完善,其丙泊酚的用量最小,麻醉时间和清醒时间最短(P<0.05)。而当用量继续升高达到2mg/kg时,其镇痛效果及丙泊酚用量与1.5mg/kg差异无统计学意义(P>0.05),不良反应却显著增加(P<0.05)。结论:丙泊酚配伍曲马多用于人工流产手术麻醉效果良好,用量应在1.5mg/kg以上,但超过2mg/kg时不良反应显著增加。
Objective.To study the analgesic efficacy of different dose of tramadol added to propofol in aboration so as to find an optimize dose. Methods. A total of 300 samples were randomly divided into five groups according to tramadol dose： group I （0 mg/kg）, group II （0. 5 mg/kg）, group III （1.0 mg/kg）,group IV （1.5 mg/kg） and groupV （2.0 mg/kg）. The patients time of consciousness loss. analgesic efficacy,conscious time, pain of uterine contraction.total propofol consumption and side effect was recorded. Results： The analgesic efficacy became better as the tramadol consumption increased and was the best when tramadol dose was above 1.5mg/kg. At this dose, the time of consciousness loss, conscious time, side effect and propofol consumption were the least. But when tramadol dose reached 2.0mg/ kg, the analgesic efficacy was not significantly different from that produced by tramadol at 2.0mg/kg, be- sides, side effects were more. Conclusions. Tamadol adding to propofol has good analgesic efficacy in abortion with little side effects, and the optimal dose of tramadol was 1.5-2.0mg/kg.
出处
《海南医学院学报》
CAS
2012年第7期956-958,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210240)~~
关键词
曲马多
丙泊酚
无痛人流
最佳剂量
Tramadol, Propofol
Induced abortion
Optimal dose
