摘要
目的:观察心脉隆胶囊(XMLJ)对高脂血症大鼠血脂及肝脂的治疗作用。方法:一次性ip维生素D 6×105U.kg-1,喂食高脂饲料4周建立大鼠高脂血症模型。建模后用不同剂量(450,300,150 mg.kg-1)的XMLJ ig治疗4周,测定大鼠血清血脂含量、过氧化损伤及内皮损伤程度,观察肝组织病理改变。结果:XMLJ各剂量均能降低总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA)、内皮素-1(ET-1)、血栓素B2(TXB2)含量,升高高密度脂蛋白胆固醇(HDL-C)、一氧化氮(NO)、前列环素(PGI2)含量和超氧化物歧化酶(SOD)活力(P<0.05),肝组织损伤减轻。结论:XMLJ能调节高脂血症大鼠血脂水平,提高机体抗氧化损伤能力,改善血管内皮功能,减轻肝脏脂肪变性程度。
hepatic tissue in intraperitoneally rats were treated blood lipid were tissue pathology. Objective： To observe the effects of Xinmailong capsules （XMLJ） on the blood lipid and the rats with hyperlipidemia. Method： The hyperlipidemia model was established by injected （ip） vitamin D 6 × 105 IU ·kg^-1 at once and given high fat forage for four weeks. Then modeling with different doses of XMLJ （450, 300, 150 mg·kg^-1 ） , and four weeks later, the levels of measured, the degree of peroxide and endothelium injury were observed, including the hepatic Result： The total cholesterol （TC）, triglyeeride （TG）, low density lipoprotein-cholesterol （LDL-C） and malondialdehyde （MDA）, endothelin-1 （ET-1）, thromboxane B2 （TXB：） at different dosages of XMLJ were significantly decreased , and the high density lipoprotein-cholesterol （HDL-C） , nitric oxide （NO） , prostacyclin （PGI2） with XMLJ were markedly increased, meanwhile, it could increase SOD activity, steatosis of hepatic tissue was significantly reduced. Conclusion： XMLJ could regulatedblood lipid level, improve antioxidation ability, enhance vascular endothelial function and relieve the liver steatosis.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第12期225-228,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
云南省腾冲制药厂开发研究项目(2010TY0910)
关键词
心脉隆胶囊
高脂血症
肝组织病理变化
过氧化
内皮损伤
Xinmailong capsules
hyperlipemia
hepatic tissue pathology
antioxidation
endothelial injury
