摘要
目的:制备黄芩苷脂质体凝胶与传递体凝胶,同时比较两者体外释透皮性能。方法:以卡波姆981为辅料制备黄芩苷脂质体凝胶与传递体凝胶,采用改良Franz扩散池,以离体小鼠皮肤为透皮屏障,紫外分光光度法测定黄芩苷的单位面积累积透皮量。结果:黄芩苷脂质体凝胶与传递体凝胶24 h单位面积累积透皮量分别为(38.00±2.51),(43.27±2.39)μg.cm-2,体外释药特性均符合Higuchi动力学方程。结论:在无压力条件下,黄芩苷传递体凝胶与普通脂质体凝胶具有相似的体外透皮性能。
Objective： To prepare baicalin liposome gel and transfersome gel, and to compare in vitro transdermal property of them. Method： Baicalin liposome gel and transfersome gel were prepared with carbopol 981 as accessories, modified Franz diffusion cell was used, isolated rat skin as transdermal barrier, unit area cumulative permeation quantity of baicalin was determined by ultraviolet spectrophotometry. Result： Unit area cumulative permeation quantities of baicalein liposome gel and transfersome gel in 24 h were （38.00± 2.51 ）, （43.27± 2. 39 ）μg·cm^-2respectively, in vitro transdermal property of them were in line with Higuchi pharmacokinetics equation. Conclusion： Without pressure, baicalin transfersome gel had similar in vitro tansdermal property with ordinary liposome gel.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第12期28-30,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
科技部"重大新药创制"科技重大专项(2009ZX09502-010)
中国中医科学院基本科研究业务费自主选题项目(ZZ20090202)
