摘要
目的评价侧隐窝注射臭氧（q）治疗腰椎间盘突出症致神经根炎对糖尿病患者血糖的影响。方法腰椎间盘突出症致神经根炎患者96例，糖尿病和非糖尿病患者各48例，糖尿病和非糖尿病患者分别采用随机数字表法各分为2组（n=24），非糖尿病-O3组（N—O3组）、非糖尿病-糖皮质激素组（N-GC组）和糖尿病-O3组（D-O3组）、糖尿病．糖皮质激素组（D—GC组）。N-O3组和D-O3组分别于侧隐窝注射30mg／L O310ml，N-GC组和D-GC组分别于侧隐窝注射复方倍他米松注射液3．5mg。于治疗前（T1）、治疗后1h（T3）、4h（T4）、治疗后1d（T5）、3d（T6）、7d（T7）时测定血糖。于T1、治疗后即刻（T2）、T5、T6、T7时行VAS评分，于T1和T7时行健康调查简表评分，于T7时评定治疗效果，记录不良反应的发生情况。结果与，T1时比较，4组治疗后VAS评分降低，T7时生理机能、躯体疼痛、情感职能、精神健康评分及N-GC组的一般健康状况评分、D—O3组和N—O3组的精力评分升高，N—GC组、D—O3组T4时及D—GC组T3-7，时血糖升高（P〈0．05）。N-O3组治疗前、后血糖比较差异无统计学意义（P〉0．05）；与N-O3组比较，N-GC组血糖升高（P〈0．05）；与D-O3组比较，D-GC组血糖升高（P〈0．05）；N-O3组、N-GC组及D—Q组、D-GC组的优良率和健康调查简表各项评分比较差异无统计学意义（P〉0．05），且未见不良反应发生。结论侧隐窝注射Q治疗腰椎间盘突出症致神经根炎对糖尿病患者血糖无明显影响。
Objective To evaluate the effect of injection of ozone （O3） through lateral recess for the treatment of radiculitis caused by lumbar disc herniation on the blood glucose in patients with diabetes mellitus. Methods Ninety-six patients with radiculitis caused by lumbar disc herniation involving 48 patients with diabetes mellitus and 48 patients without diabetes mellitus were enrolled in the study. The diabetic or non-diabetic patients were randomly divided into 2 groups （ n = 24 each） ： non-diabetic patients-O3 group （group N-O3 ）, non-diabetic patients-glucocorticoid group （group N-GC）, diabetic patients-O3 group （group D-O3 ）, and diabetic patients-glu- cocorticoid group （group D-GC）. In N-O3 and D-O3 groups, 30 mg/L O3 10 ml was injected via the lateral recess. In N-GC and D-GC groups, compound betamethasone injection 3.5 mg was injected via the lateral recess. The blood glucose level was measured before treatment （T1）, 1 and 4 h after treatment （T3.4）, and 1, 3 and 7 days after treatment （T5-7）. VAS score was recorded at T1, immediately after treatment （T2）, and at T5.7. The patients＇ quality of life was measured using the Medical Outcomes Study 36-Item Short-Form Health Survey （MOS SF- 36 Health Survey） questionnaire at T1,7. The therapeutic effect was evaluated at T7 The side effects were recorded.Results Compared with the baseline value at T1, VAS scores were significandy decreased after treatment, while the MOS SF-36 Health Survey questionnaire scores for physical functioning, bodily pain, role emotional, and mental health in all groups, for general health in group N-GC, and for vitality in groups D-O3 and N-O3 were sig- nificantly increased at TT, and the blood glucose level was significantly increased at T4 in groups N-GC and D-O3, and at T3_7 in group D-GC （ P 〈 0.05）. There was no significant change in the blood glucose level before and after treatment in group N-O3. The blood glucose level was significantly higher in group N-CC than in group N-O3, and in group D-GC than in group D-O3 （P 〈 0.05）. There were no significant differences in the excellent and good rates and all the MOS SF-36 Health Survey questionnaire scores among all groups. No side effects were found in the study. Conclusion Injection of ozone through lateral recess for treatment of radiculitis caused by lumbar disc herniation exerts no influence on the blood glucose level in patients with diabetes mellitus.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2012年第4期397-400,共4页
Chinese Journal of Anesthesiology
基金
国家自然科学基金（30972844）
山东省自然科学基金（Y2006C69,ZR2010HM097）
关键词
臭氧
神经根病
血糖
糖尿病
腰椎
椎间盘移位
Ozone
Radiculopathy
Blood glucose
Diabetes mellitus
Lumbar vertebrae
Intervertebral disk displacement
